Now showing items 111-120 of 177
Polydiacetylene Liposome Microarray Toward Influenza A Virus Detection: Effect of Target Size on Turn‐On Signaling
(WILEY‐VCH Verlag, 2013-05-14)
Target size effect on the sensory signaling intensity of polydiacetylene (PDA) liposome microarrays was systematically investigated. Influenza A virus M1 peptide and M1 antibody were selected as a probe–target pair. While ...
The Role of Topological Constraints in RNA Tertiary Folding and Dynamics.
(2014)
Functional RNA molecules must fold into highly complex three-dimensional (3D) structures and undergo precise structural dynamics in order to carry out their biological functions. However, the principles that govern RNA 3D ...
Symmetry Assembled Supramolecular Protein Cages: Investigating a Strategy for Constructing New Biomaterials.
(2011)
In nature, the assembly of individual protein subunits into larger quaternary structures allows new biological properties to emerge as consequence of the higher order structure. The biological function and physical properties ...
Probing microRNA Activity in vitro and inside Cells using Single Molecule Microscopy.
(2012)
Non-coding RNAs (ncRNAs) outnumber their protein-coding counterparts, yet their presumably diverse functions are still ill-understood. This thesis reports the development of two novel single-molecule methods to probe the ...
A concept‐wide association study to identify potential risk factors for nonadherence among prevalent users of antihypertensives
(Wiley Periodicals, Inc., 2019-10)
PurposeWe sought to determine whether an association study using information contained in clinical notes could identify known and potentially novel risk factors for nonadherence to antihypertensive medications.MethodsWe ...
Fluoride catalyzed rearrangements of polysilsesquioxanes, mixed Me, vinyl T 8 , Me, vinyl T 10 and T 12 cages
(John Wiley & Sons, Ltd., 2010-08)
Insoluble mixtures of polyvinylsilsesquioxane, -(vinylSiO 1.5 ) n - PVS, and polymethylsilsesquioxanes, -(MeSiO 1.5 ) n - PMS, in THF at ambient when treated with catalytic amounts (1–5 mol%) of fluoride ion introduced ...
Rate constant of the reaction of chlorine atoms with methanol over the temperature range 291–475 K
(Wiley Subscription Services, Inc., A Wiley Company, 2010-02)
The rate constant of the reaction Cl + CH 3 OH ( k 1 ) has been measured in 500–950 Torr of N 2 over the temperature range 291–475 K. The rate constant determination was carried out using the relative rate technique with ...
Timing of androgen deprivation therapy use and fracture risk among elderly men with prostate cancer in the United States
(John Wiley & Sons, Ltd, 2012-01)
Purpose Fractures are a recognized consequence of androgen deprivation therapy (ADT); however, less is known about the incidence of fracture in relation to the timing of ADT use or the impact of fracture on mortality in ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...
The Application of Mass Spectrometry-Based Label-Free Quantitative Proteomic Strategies in Cancer Stem Cell Research.
(2011)
The application of mass spectrometry(MS) has dramatically expanded the frontiers of the analysis of protein expression in biological samples. This thesis addresses the application of a MS-based label-free strategy to analyze ...