Now showing items 171-177 of 177
Specialized Metabolites and Related Biosynthetic Enzymes in Tomato Glandular Trichomes: Defining Biological Functions of Specific Gland Types.
(2011)
Trichomes are tiny appendages that grow out from the surfaces of leaves, stems, flowers, and other above-ground parts of many plants. They contribute to important biological functions such as determent of herbivores, ...
Structural and Dynamic Basis for Assembly of the HIV-1 TAR-Tat Ribonucleoprotein Complex
(2011)
The transactivation response element (TAR), located at the 5' end of the HIV-1 genome, regulates the transcription elongation step of viral RNA. The TAR stem-loop binds the HIV viral transactivator protein (Tat), which ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Characterization of the Amyloidogenic Peptides Amylin and PAP248-286.
(2012)
Many diseases in the aging population are associated with a class of peptide that aggregates to form amyloidogenic fibers through a misfolding from random coil, to cross β-sheet fibrils. Diseases such as Alzheimer’s disease, ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Characterization of the Dynamic Interactions of Transcriptional Activators
(2010)
Transcription is initiated through a series of coupled binding equilibria between transcriptional activators and their array of protein targets within the transcriptional machinery. However, previous efforts to kinetically ...