Now showing items 121-130 of 177
Exploring a "Nature-Inspired" Strategy for Enhancing the Pharmacology of Small Molecules: Towards the Development of Next Generation Anti-Infectives.
(2011)
HIV is now a pandemic of staggering proportions. Unfortunately, the current generation of antiretroviral therapeutics is only partially and temporarily effective in suppressing viral replication due to rapid metabolism ...
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.
(2015)
Phosphopantetheine is an essential biomolecule required for life. The enzyme phosphopantothenoylcysteine synthetase (PPCS) incorporates the reactive thiol moiety in the Coenzyme A (CoA) biosynthetic pathway. Two types of ...
Novel Modulators of Rho Transcriptional Signaling in Cancer.
(2012)
Rho A and Rho C, members of the Rho GTPase family, have been found to have important roles in the metastases of multiple cancers, including melanoma, prostate, and breast cancer. While Rho GTPases are known to have effects ...
Insights on Metal Ions and Misfolded Proteins in Alzheimer's Disease Using Flavonoid Derivatives and X-ray Fluorescence Microscopy.
(2013)
The incidence of Alzheimer’s disease (AD) worldwide has been accelerating at a staggering rate, demonstrating the need to understand its origins clearly. Misfolded proteins such as amyloid-beta have been believed to ...
Mapping, Tracking and Modeling the Movements of Single Membrane-Bound Transcription Activator Proteins in Live Vibrio cholerae.
(2014)
Cholera has been known since ancient times, yet there is still no cure. Vibrio cholerae bacteria cause cholera by producing cholera toxin. Cholera toxin production is regulated by the protein ToxT, which itself is regulated ...
Towards Understanding and Overcoming the Antibiotic Resistance Conferred by Acetyltransferases.
(2012)
Aminoglycoside (AG) antibiotics have been widely applied to the treatment of bacterial infections since the discovery of streptomycin. Having enjoyed over 60 years of clinical success, AGs have encountered problems with ...
Folate Binding Protein as a Therapeutic Natural Nanotechnology
(2018)
Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing critical roles in biotransport, ...
(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan.
(2012)
Chapter 1: We evaluated the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan ...
Ultrafast Hydration Dynamics Near Extended Macromolecular Interfaces
(2019)
Liquid water is arguably the most complex, but interesting chemical, enabling development and sustenance of life. The tetrahedral geometry of the water molecule allows the formation of a dense network of hydrogen bonds ...
A Tale of Two RNAs: Single Molecule Investigation of the Conformation, Dynamics and Ligand Binding to the PreQ1 and T-box Riboswitches.
(2014)
Riboswitches are structured mRNA domains that can bind cellular metabolites and control gene expression of downstream genes mainly via transcription attenuation or inhibition of translation initiation. Although structures ...