Now showing items 131-140 of 177
Targeting the Activator Interaction Domain of Mediator Subunit Med25.
(2016)
The Activator Interaction Domain of Mediator subunit Med25 is a coactivator binding partner for a number of transcriptional activators implicated in diverse cellular processes including the hijacking of transcriptional ...
Functional Analysis of Protein S-Palmitoylation Enzymes.
(2015)
Protein S-palmitoylation is a dynamic, hydrophobic, post-translational modification of cysteine residues that is required for the spatiotemporal organization of hundreds of proteins. In turn, protein palmitoylation contributes ...
Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy
(2016)
Misregulation of tau, an intrinsically disordered protein, is implicated in Alzheimer’s disease (AD) and more than 15 related tauopathies. These diseases are characterized by the accumulation of tau aggregates into insoluble ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Advances in Coarse-grained Models for Protein Folding and Protein-protein Interactions
(2019)
Almost all biological functions rely on the dynamics of proteins. Protein folding and protein-protein interactions are the two most fundamental problems of protein dynamics. Molecular dynamics (MD) simulation is a powerful ...
Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids.
(2013)
Transient and moderate affinity protein-protein interactions (PPIs) play a critical role in the regulation of essential cellular processes including protein folding, ubiquitylation, and transcription. A number of disease ...
Structural and Biochemical Insights into Methylation Site and State Specificity of JMJD2 Lysine Demethylases.
(2012)
The human JMJD2/KDM4 family of histone lysine demethylases comprises four homologs: JMJD2A, JMJD2B, JMJD2C and JMJD2D. These enzymes have been implicated in a number of biological processes such as transcriptional activation, ...
A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides
(2018)
Cap-dependent protein translation (CdT) is dysregulated in many types of cancer and leads to overexpression of oncogenes promoting angiogenesis, evasion of apoptosis, and cell proliferation. The protein-protein interactions ...
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Decoding the Bio-Assembly of Hapalindole-Type Alkaloids from Cyanobacteria for Drug Discovery
(2017)
Biosynthetic exploration of natural products provides a promising opportunity to produce novel bioactive molecules for drug development. Hapalindole-type alkaloids are a large group of secondary metabolites isolated from ...