Now showing items 51-60 of 654
Extent and distribution of linkage disequilibrium in the Old Order Amish
(Wiley Subscription Services, Inc., A Wiley Company, 2010-02)
Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not ...
Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes
(Wiley Periodicals, Inc.Prentice‐Hall, 2019-07)
With the availability of large‐scale biobanks, genome‐wide scale phenome‐wide association studies are being instrumental in discovering novel genetic variants associated with clinical phenotypes. As increasing number of ...
LabCaS: Labeling calpain substrate cleavage sites from amino acid sequence using conditional random fields
(Wiley Subscription Services, Inc., A Wiley Company, 2013-04)
The calpain family of Ca 2+ ‐dependent cysteine proteases plays a vital role in many important biological processes which is closely related with a variety of pathological states. Activated calpains selectively cleave ...
Single-Molecule Microscopy Studies of Interactions between Alzheimer's Amyloid- (1-40) and Amyloid- (1-42) on the Membrane.
(2014)
Two amyloid-β peptides (Aβ40 and Aβ42) feature prominently in the extracellular brain deposits associated with Alzheimer’s disease. While Aβ40 is the prevalent form in the cerebrospinal fluid, the fraction of Aβ42 increases ...
Glycosylation via Transition‐Metal Catalysis: Challenges and Opportunities
(American Chemical SocietyWiley Periodicals, Inc., 2016-10)
Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes
(Wiley Periodicals, Inc., 2018-09)
Islet transplantation is a promising therapeutic option for type 1 diabetes mellitus, yet the current delivery into the hepatic portal vasculature is limited by poor engraftment. Biomaterials have been used as a means to ...
Meta-analysis of genetic association studies and adjustment for multiple testing of correlated SNPs and traits
(Wiley Subscription Services, Inc., A Wiley Company, 2010-11)
Meta-analysis has become a key component of well-designed genetic association studies due to the boost in statistical power achieved by combining results across multiple samples of individuals and the need to validate ...
A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells
(Wiley Subscription Services, Inc., A Wiley Company, 2010-11-01)
We have developed a bilayer microfluidic system with integrated transepithelial electrical resistance (TEER) measurement electrodes to evaluate kidney epithelial cells under physiologically relevant fluid flow conditions. ...
Lysosomal phospholipase A 2 : A novel player in host immunity to Mycobacterium tuberculosis
(Wiley Periodicals, Inc., 2014-08)
Analyzing Proteinâ Protein Interactions from Affinity Purificationâ Mass Spectrometry Data with SAINT
(Wiley Periodicals, Inc., 2012-09)
Significance Analysis of INTeractome (SAINT) is a software package for scoring proteinâ protein interactions based on labelâ free quantitative proteomics data (e.g., spectral count or intensity) in affinity purificationâ ...