Now showing items 21-30 of 654
The Role of Environmental Heterogeneity in Meta‐Analysis of Gene–Environment Interactions With Quantitative Traits
(Wiley, 2014-07)
With challenges in data harmonization and environmental heterogeneity across various data sources, meta‐analysis of gene–environment interaction studies can often involve subtle statistical issues. In this paper, we study ...
Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)
(WILEY-VCH Verlag, 2010-01-18)
In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most ...
Biological Network Exploration with Cytoscape 3
(Association for the Advancement of Artificial IntelligenceWiley Periodicals, Inc., 2014-09)
Cytoscape is one of the most popular open‐source software tools for the visual exploration of biomedical networks composed of protein, gene, and other types of interactions. It offers researchers a versatile and interactive ...
Prots: A fragment based protein thermo‐stability potential
(Wiley Subscription Services, Inc., A Wiley Company, 2012-01)
Designing proteins with enhanced thermo‐stability has been a main focus of protein engineering because of its theoretical and practical significance. Despite extensive studies in the past years, a general strategy for ...
Genome‐Wide Family‐Based Linkage Analysis of Exome Chip Variants and Cardiometabolic Risk
(Wiley Periodicals, Inc., 2014-04)
Linkage analysis of complex traits has had limited success in identifying trait‐influencing loci. Recently, coding variants have been implicated as the basis for some biomedical associations. We tested whether coding ...
Methods for meta‐analysis of multiple traits using GWAS summary statistics
(Oxford University PressWiley Periodicals, Inc., 2018-03)
Genome‐wide association studies (GWAS) for complex diseases have focused primarily on single‐trait analyses for disease status and disease‐related quantitative traits. For example, GWAS on risk factors for coronary artery ...
Highly polarized T h17 cells induce EAE via a T ‐bet independent mechanism
(Wiley Periodicals, Inc., 2013-11)
Existence of a Glassy Layer in the Polymer‐ N anosheet Interface: Evidence from Molecular Dynamics
(Wiley Periodicals, Inc., 2014-01)
Rho/MRTF Pathway Signaling and Small-Molecule Inhibitor Development in Systemic Sclerosis and Metastatic Melanoma
(2015)
Rho GTPases regulate multiple biological functions; most notably, they stimulate formation of F-actin stress fiber formations. Through their modulation of the actin cytoskeleton Rho GTPases also activate gene transcription ...
A guided tour of the Trans-Proteomic Pipeline
(WILEY-VCH Verlag, 2010-03)
The Trans-Proteomic Pipeline (TPP) is a suite of software tools for the analysis of MS/MS data sets. The tools encompass most of the steps in a proteomic data analysis workflow in a single, integrated software system. ...