Now showing items 11-20 of 22
Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
(Wiley Periodicals, Inc., 2019-01)
Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated ...
Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells
(Wiley Periodicals, Inc.Systems Biology, 2017-09)
The development of resistance to targeted therapeutics is a challenging issue for the treatment of cancer. Cancers that have mutations in BRCA, a DNA repair protein, have been treated with poly(ADP‐ribose) polymerase (PARP) ...
Production of cellulosic organic acids via synthetic fungal consortia
(Wiley Periodicals, Inc., 2018-04)
Consolidated bioprocessing (CBP) is a potential breakthrough technology for reducing costs of biochemical production from lignocellulosic biomass. Production of cellulase enzymes, saccharification of lignocellulose, and ...
Sensitive detection of glucagon aggregation using amyloid fibril‐specific antibodies
(Wiley Periodicals, Inc., 2019-08)
Sensitive detection of protein aggregates is important for evaluating the quality of biopharmaceuticals and detecting misfolded proteins in several neurodegenerative diseases. However, it is challenging to detect extremely ...
Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor
(Wiley Subscription Services, Inc., A Wiley Company, 2011-02)
The effects of the antimicrobial tylosin on a methanogenic microbial community were studied in a glucose-fed laboratory-scale anaerobic sequencing batch reactor (ASBR) exposed to stepwise increases of tylosin (0, 1.67, and ...
Assessing the ability of human endothelial cells derived from induced‐pluripotent stem cells to form functional microvasculature in vivo
(Wiley Periodicals, Inc., 2019-02)
Forming functional blood vessel networks is a major clinical challenge in the fields of tissue engineering and therapeutic angiogenesis. Cell‐based strategies to promote neovascularization have been widely explored, but ...
384 hanging drop arrays give excellent Z ‐factors and allow versatile formation of co‐culture spheroids
(Wiley Subscription Services, Inc., A Wiley Company, 2012-05)
We previously reported the development of a simple, user‐friendly, and versatile 384 hanging drop array plate for 3D spheroid culture and the importance of utilizing 3D cellular models in anti‐cancer drug sensitivity ...
Laminar shear stress elicit distinct endothelial cell e‐selectin expression pattern via TNFα and IL‐1β activation
(Wiley Subscription Services, Inc., A Wiley Company, 2013-03)
The ability to discriminate cell adhesion molecule expression between healthy and inflamed endothelium is critical for therapeutic intervention in many diseases. This study explores the effect of laminar flow on TNFα‐induced ...
Regulated expression of polysaccharide utilization and capsular biosynthesis loci in biofilm and planktonic Bacteroides thetaiotaomicron during growth in chemostats
(Wiley Periodicals, Inc., 2014-01)
Bacteroides thetaiotaomicron is a prominent member of the human distal gut microbiota that specializes in breaking down diet and host‐derived polysaccharides. While polysaccharide utilization has been well studied in B. ...
Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor
(Wiley Periodicals, Inc., 2019-11)
Breast cancer cells experience a range of shear stresses in the tumor microenvironment (TME). However most current in vitro three‐dimensional (3D) models fail to systematically probe the effects of this biophysical stimuli ...