Now showing items 31-40 of 369
Curcumin downregulates the PI3K–AKT–mTOR pathway and inhibits growth and progression in head and neck cancer cells
(John Wiley & Sons, Ltd., 2020-12)
Curcumin, a polyphenol isolated from the rhizome of Curcuma longa, has been studied because of its antioxidant, antimicrobial, and antiinflammatory properties. This study aimed to evaluate the effects of curcumin on head ...
Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting
(Wiley Periodicals, Inc., 2020-12)
Protein nanoparticles are a promising approach for nanotherapeutics, as proteins combine versatile chemical and biological function with controlled biodegradability. In this work, the development of an adaptable synthesis ...
Diverse Nanoassemblies of Graphene Quantum Dots and Their Mineralogical Counterparts
(Wiley Periodicals, Inc.American Chemical Society, 2020-05-25)
Complex structures from nanoparticles are found in rocks, soils, and sea sediments but the mechanisms of their formation are poorly understood, which causes controversial conclusions about their genesis. Here we show that ...
Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor‐Induced Combinatorial Pairing of Stig Cyclases
(Wiley Periodicals, Inc.Academic Press, 2020-05-18)
Stereospecific polycyclic core formation of hapalindoles and fischerindoles is controlled by Stig cyclases through a three‐step cascade involving Cope rearrangement, 6‐exo‐trig cyclization, and a final electrophilic aromatic ...
Physical aging of polystyrene blocks under three‐dimensional soft confinement in PS‐b‐poly(n‐butyl methacrylate) diblock copolymer: Two equilibrations on the way
(John Wiley & Sons, Inc., 2021-02-15)
Polystyrene‐block‐poly(n‐butyl methacrylate) (PS‐b‐PnBMA) was used to investigate three‐dimensional (3D) soft confinement effect on physical aging of the PS block therein. The soft confinement is constructed by phase‐separated ...
[Ga3+8Sm3+2, Ga3+8Tb3+2] Metallacrowns are Highly Promising Ratiometric Luminescent Molecular Nanothermometers Operating at Physiologically Relevant Temperatures
(Wiley Periodicals, Inc.Elsevier, 2020-11-02)
Nanothermometry is the study of temperature at the submicron scale with a broad range of potential applications, such as cellular studies or electronics. Molecular luminescent- based nanothermometers offer a non- contact ...
Isolation of Circulating Biomarkers for Liquid Biopsy using Immunoaffinity- Based Stimuli- Responsive Hybrid Hydrogel Beads
(Wiley Periodicals, Inc., 2021-06)
This work presents chemically stable and biodegradable hydrogel beads for the isolation of circulating tumor cells (CTCs) and circulating exosomes in liquid biopsy. The liquid biopsy hydrogel beads (LBbeads) consisting of ...
Direct noninvasive 1H NMR analysis of stream water DOM: Insights into the effects of lyophilization compared with whole water
(ElsevierWiley Periodicals, Inc., 2021-05)
NMR spectroscopy is widely used in the field of aquatic biogeochemistry to examine the chemical structure of dissolved organic matter (DOM). Most aquatic DOM analyzed by proton NMR (1H NMR) is concentrated mainly by ...
Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products
(Wiley Periodicals, Inc.Humana Press, 2021-05-07)
Many biologically active natural products are synthesized by nonribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These megasynthetases are comprised of modules which are subdivided into ...
Designing a Single Protein‐Chain Reporter for Opioid Detection at Cellular Resolution
(Wiley Periodicals, Inc.Academic Press, 2021-06-07)
Mu‐opioid receptor (MOR) signaling regulates multiple neuronal pathways, including those involved in pain, reward, and respiration. To advance the understanding of MOR’s roles in pain modulation, there is a need for ...