Now showing items 11-20 of 22
Aberrant Epigenetic Patterning Defines an Aggressive Molecular Subtype of Adrenocortical Carcinoma and Exposes a Tissue-Specific Therapeutic Vulnerability
(2023)
The adrenal glands are endocrine organs that produce steroid hormones and catecholamines critical for life. Adrenocortical carcinoma (ACC) is a rare cancer of these glands. Up to 75% of patients with ACC develop metastases, ...
Probing Adhesion GPCR Mechanisms via High Throughput Screening for Novel GPR56 Modulatory Compounds
(2023)
Adhesion G Protein-Coupled receptors (AGPCRs) are a poorly understood subset of class B GPCRs that comprises 33 members across nine subfamilies. These GPCRs are unique in their possession of large extracellular regions ...
Molecular Mechanisms of G?i Signaling Selectivity
(2023)
Nearly all of human physiology is under the control of G protein-coupled receptors (GPCRs), which transmit signals from extracellular stimuli to affect intracellular processes. The heterotrimeric G proteins that these ...
Intracellular Trafficking Regulators for the Atherogenic Lipoproteins LDL and Lp(a)
(2022)
Elevated levels of low-density lipoprotein (LDL) and its derivative lipoprotein(a) (Lp(a)) in the bloodstream are directly implicated in the development and progression of atherosclerotic cardiovascular diseases (ASCVD). ...
Characterizing the Function of CSLD Proteins During Plant Cell Wall Deposition in Arabidopsis
(2020)
As one of the most significant features of plant cells, the cell wall not only defines plant cell shape but also provides strength and rigidity to the plant. During plant development, changes in cell shape are primarily ...
Functional Characterization of Fibrinolysis-Modulating Proteins Using High Throughput Phage Display
(2020)
The advent of modern high throughput sequencing (HTS) technology has resulted in the resurgence of phage display as a powerful technique in screening peptide and protein libraries for mutations and/or protein fragments ...
Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer
(2021)
Metabolic reprogramming in cancer was first described in the early to mid-1900s and later labeled as a hallmark. Rapidly proliferating cells require sufficient concentrations of nucleotides and other biomass precursor ...
Structural and Biochemical Mechanisms of MLL1 Activation on Chromatin
(2022)
Transcription is a critical process by which cells regulate temporal and spatial expression of genes. In eukaryotes, histone H3 lysine 4 methylation by the MLL/SET1 family histone methyltransferases is enriched at transcription ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology
(John Wiley & Sons, Inc., 2023-02)
Inorganic arsenic (iAs) is one of the largest toxic exposures to impact humanity worldwide. Exposure to iAs during pregnancy may disrupt the proper remodeling of the epigenome of F1 developing offspring and potentially ...