Now showing items 21-30 of 55
Effects of stereoisomeric structure and bond location on the ignition and reaction pathways of hexenes
(Wiley Periodicals, Inc., 2021-02)
The current work presents new experimental autoignition and speciation data on the two cis- hexene isomers: cis- 2- hexene and cis- 3- hexene. The new data provide insights on the effects of carbon- carbon double ...
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo
(Wiley Periodicals, Inc., 2020-01)
Metastases are preceded by stochastic formation of a hospitable microenvironment known as the premetastatic niche, which has been difficult to study. Herein, we employ implantable polycaprolactone scaffolds as an engineered ...
CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts
(Wiley Periodicals, Inc., 2021-04)
This study elucidates the mechanism of CCL25 and CCR9 in rheumatoid arthritis (RA). RA synovial fluid (SF) expresses elevated levels of CCL25 compared to OA SF and plasma from RA and normal. CCL25 was released into RA SF ...
Optimal dynamic treatment regime estimation using information extraction from unstructured clinical text
(Chapman and Hall/CRCWiley Periodicals, Inc., 2022-04)
The wide-scale adoption of electronic health records (EHRs) provides extensive information to support precision medicine and personalized health care. In addition to structured EHRs, we leverage free-text clinical information ...
The holy basil administration diminishes the NF-kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma
(John Wiley & Sons, Ltd., 2022-04)
Bacterial pneumonia is one of the most important causes of mortality in the United States. The bacteria Klebsiella pneumoniae (KP) accounts for a significant proportion of community and hospital-acquired infections. Here, ...
Molecular investigation of the tandem Tudor domain and plant homeodomain histone binding domains of the epigenetic regulator UHRF2
(John Wiley & Sons, Inc., 2022-03)
Ubiquitin- like containing PHD and ring finger (UHRF)1 and UHRF2 are multidomain epigenetic proteins that play a critical role in bridging crosstalk between histone modifications and DNA methylation. Both proteins contain ...
FRACPRED- 2D- PRM: A Fraction Prediction Algorithm- Assisted 2D Liquid Chromatography- Based Parallel Reaction Monitoring- Mass Spectrometry Approach for Measuring Low- Abundance Proteins in Human Plasma
(Wiley Periodicals, Inc., 2020-12)
Multidimensional fractionation- based enrichment methods improve the sensitivity of proteomic analysis for low- abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive ...
3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing
(John Wiley & Sons, Inc., 2020-04)
MultiFlow® DNA Damage—p53, γH2AX, Phospho‐Histone H3 is a miniaturized, flow cytometry‐based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to ...
Combining sequence data from multiple studies: Impact of analysis strategies on rare variant calling and association results
(Wiley Periodicals, Inc., 2020-01)
Individual sequencing studies often have limited sample sizes and so limited power to detect trait associations with rare variants. A common strategy is to aggregate data from multiple studies. For studying rare variants, ...