Now showing items 21-27 of 27
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
High Throughput Experimentation Facilitated Development of Amine-Acid Cross Coupling Reactions
(2023)
High throughput experimentation (HTE) is an important technique which can expedite the hit-to-lead process in drug discovery. The first chapter of this thesis reviews reported applications using HTE in medicinal chemistry ...
Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis
(2022)
Tuberculosis (TB) is an infectious pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). It is the leading cause of death from a single bacterial pathogen and second, only to COVID-19, as the deadliest ...
Thermodynamic and Mathematical Relationships for Predicting Cocrystal Stability and Controlling Dissolution - Supersaturation - Precipitation Behavior
(2020)
Although pharmaceutical cocrystals have emerged as a useful strategy for enhancing the solubility, dissolution, and oral bioavailability of poorly water-soluble drugs, their development has thus far been marked by a lack ...
Transparent and Self-Healing Elastomers for Reconfigurable 3D Materials
(Wiley Periodicals, Inc., 2022-12)
Transparent soft materials are widely used in applications ranging from packaging to flexible displays, wearable devices, and optical lenses. Nevertheless, soft materials are susceptible to mechanical damage, leading to ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...