Now showing items 21-29 of 29
Application of Ultra-low Circulating Biomarkers and Single Cell Analysis from Solid Tumors with Single Molecule Resolution
(2020)
Circulating tumor cells (CTCs) and extracellular vesicles (EVs) carry tumor-derived cargo in the circulation and provide the potential for minimally invasive patient monitoring. These circulating biomarkers have both been ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
Multiscale Modeling of Tuberculosis Disease and Treatment to Optimize Antibiotic Regimens
(2020)
Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at ...
Fabrication of Non-Spherical Biodegradable Particles for Drug Delivery Applications and Studying the Impact of Shape on the Efficacy of Particulate Carriers
(2020)
Biodegradable particles are used to specifically deliver drugs to diseased sites to increase their efficacy and minimize their side effects. Until now, most of the drug delivery platforms have been spherical in their shape ...
Isolation and Characterization of Circulating Biomarkers to Predict Patient Outcomes in Late-Stage Non-Small Cell Lung Cancer
(2021)
This work hypothesizes that the molecular characterization of extracellular vesicles (EVs) and circulating tumor cells (CTCs), biomarkers found in peripheral blood draws, can be used to monitor, and predict, treatment ...
Transparent and Self-Healing Elastomers for Reconfigurable 3D Materials
(Wiley Periodicals, Inc., 2022-12)
Transparent soft materials are widely used in applications ranging from packaging to flexible displays, wearable devices, and optical lenses. Nevertheless, soft materials are susceptible to mechanical damage, leading to ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...