Now showing items 31-40 of 57
Evaluating the Calibration and Power of Three Gene‐Based Association Tests of Rare Variants for the X Chromosome
(Wiley Periodicals, Inc., 2015-11)
Although genome‐wide association studies (GWAS) have identified thousands of trait‐associated genetic variants, there are relatively few findings on the X chromosome. For analysis of low‐frequency variants (minor allele ...
Frequent side chain methyl carbon‐oxygen hydrogen bonding in proteins revealed by computational and stereochemical analysis of neutron structures
(Oxford University PressWiley Periodicals, Inc., 2015-03)
The propensity of backbone Cα atoms to engage in carbon‐oxygen (CH···O) hydrogen bonding is well‐appreciated in protein structure, but side chain CH···O hydrogen bonding remains largely uncharacterized. The extent to which ...
Using PepExplorer to Filter and Organize De Novo Peptide Sequencing Results
(Wiley Periodicals, Inc.Humana Press, 2015-09)
PepExplorer aids in the biological interpretation of de novo sequencing results; this is accomplished by assembling a list of homolog proteins obtained by aligning results from widely adopted de novo sequencing tools against ...
Targeting CDC25B-CDK2/Cyclin A Activity Using Chemical Biology Approaches
(2015)
The cell cycle is a fundamental process of cell biology, and its progression is highly regulated. A critical mode of regulation for proper advancement of the cell cycle is the activation of the CDKs by the CDC25 family of ...
Mechanisms of mRNA Regulation by Pumilio and Nanos.
(2015)
Drosophila Pumilio and Nanos proteins function together to control development, germline stem cell maintenance, and neurological functions. How Pumilio and Nanos collaborate is not completely understood. Pumilio belongs ...
Biophysical Insights into the Role of Amyloid-Beta Misfolding in Alzheimer’s Disease Pathogenesis.
(2015)
Amyloids are protein aggregates that build up as plaques in various tissues in the body and are associated with a number of diseases. Of the amyloidoses, Alzheimer’s disease (AD) is the most known and socially distressing. ...
Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding
(Wiley, 2015-08)
Cooperative binding mechanisms are a common feature in biology, enabling a diverse range of protein‐based molecular machines to regulate activities ranging from oxygen uptake to cellular membrane transport. Much, however, ...
Methods for Association Analysis and Meta‐Analysis of Rare Variants in Families
(Wiley Periodicals, Inc.Springer‐Verlag, 2015-05)
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety ...
Origin of Low Detection Limit and High Selectivity of Roche Accu‐Chek Test Strips that Enables Measurement of Tear Glucose Levels
(WILEY‐VCH Verlag, 2015-03)
Tear glucose measurements have been suggested as a potential alternative to blood glucose monitoring for diabetic patients. While previous work has reported a correlation between blood and tear glucose levels in humans, ...
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.
(2015)
Phosphopantetheine is an essential biomolecule required for life. The enzyme phosphopantothenoylcysteine synthetase (PPCS) incorporates the reactive thiol moiety in the Coenzyme A (CoA) biosynthetic pathway. Two types of ...