Now showing items 51-57 of 57
Comparative Investigation of Key Biosynthetic Transformations in Fungal Indole Alkaloid Natural Product Pathways.
(2015)
My dissertational research has focused on the elucidation of three key biosynthetic steps involved in the formation of fungal indole alkaloid natural products. Beginning with the comparative analysis of four assembled ...
Design and Characterization of Bifunctional Glucocorticoid Ligands Capable of Producing Novel Transcriptional Profiles.
(2015)
The process of transcription underlies the expression of all gene profiles. Normal expression is caused by carefully coordinating the assembly of transcriptional proteins at specific genes, a procedure mediated through ...
Strategies for Modulating the Diverse Activities of Heat Shock Protein 70.
(2015)
Heat shock protein 70 (Hsp70) is an essential regulator of protein homeostasis. Dysfunction of protein homeostasis is directly linked to many diseases, including cancer and neurodegeneration. Thus, an understanding of ...
Dissecting BMI1 Protein-Protein Interactions Through Chemical Biology.
(2015)
BMI1 has emerged as a key oncogenic factor in many cancers, associated with unregulated cellular proliferation, tumor metastasis and cancer-initiating cell self-renewal. BMI1 is best characterized as a component of the ...
Profiling Ester Prodrug Activation: An Activity Based Protein Profiling (ABPP) Approach.
(2015)
Determining the identity of prodrug activating enzyme(s) is key to understanding the mechanistic basis for enhanced cellular delivery, biodistribution, and prodrug stability. In addition, understanding species-specific ...
UDP-Glucose: Glycoprotein Glucosyltransferase (UGGT1) Promotes Substrate Solubility in the Endoplasmic Reticulum.
(2015)
Protein folding in the endoplasmic reticulum (ER) is error-prone, and ER quality control processes exist (ERQC) to ensure only correctly folded proteins are exported from the ER en route to the Golgi compartment. Glycoproteins ...
Chemical Modulation of Phospho-Signaling Pathways Involved in Cancer.
(2015)
Advancements in our understanding of the molecular causes of cancer have led to the therapeutic targeting of key enzymes involved in cell growth. Kinase inhibitors have been the most successful forms of such targeted therapy ...