Now showing items 1041-1049 of 1049
Environmental Health Impacts of Informal Electronic Waste Recycling
(2019)
Electronic waste, “E-waste”, is the fastest growing waste stream globally. Informal e-waste recycling lacks the policy and regulatory controls found in formal industry, creating health hazards for workers and communities, ...
The Role of Type I Interferons in TLR7-Mediated Lupus and UVB-Induced Immune Cell Responses
(2019)
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects up to .02% of the US population and nearly 90% of patients are women. These SLE patients experience devastating organ damage mediated by autoantibody ...
Data-Driven Environmental System Analysis: Addressing Data Gaps in Life Cycle Assessment
(2019)
Life Cycle Assessment (LCA) is a widely used analytical tool in environmental system analysis. LCA examines the environmental impacts of a product along its whole life cycle, including raw materials extraction, manufacturing, ...
Statistical Learning Methods for Electronic Health Record Data
(2019)
In the current era of electronic health records (EHR), use of data to make informed clinical decisions is at an all-time high. Although the collection, upkeep and accessibility of EHR data continues to grow, statistical ...
Lifestyle Factors During the Midlife and Subclinical Carotid Atherosclerosis Later in Life: The Study of Women's Health Across the Nation
(2019)
Menopause has adverse effects on cardiometabolic profiles that are linked to an accelerated progression of atherosclerosis and increased risk of cardiovascular disease in women. Thus, the menopausal transition may be a ...
Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation
(2019)
Epitope density appears to be a critical factor in pathogens that can elicit effective immune responses. All the viruses that have efficacious FDA-approved target vaccines have high surface densities of antigens. HIV, on ...
Identification of the PH Domain of Scaffold Protein SH2B1 as a Critical Regulator of Energy Balance and Glucose Metabolism
(2019)
Obesity is a growing epidemic but the cellular and molecular mechanisms underlying obesity are still not well understood. Mutations in the adaptor protein SH2B1 have been identified in individuals with severe early-onset ...
Bacterial Cytochrome P450-Mediated Biosynthesis of Non-Symmetrical Diketopiperazine Dimers: Discovery, Catalysis, and Structure
(2019)
The simplest cyclic peptide is composed of two amino acids and forms a 2,5- diketopiperazine (DKP). Diketopiperazine containing natural products can be found from eukaryotic, fungal, and bacterial sources and are present ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...