Now showing items 871-880 of 897
Development and Application of Virtual Screening Methods for G Protein-Coupled Receptors
(2018)
G protein-coupled receptors (GPCR) constitute one of the largest family of transmembrane proteins that have been implicated in a multitude of diseases, including cancer and diabetes, and have been an important target in ...
Insights into the Molecular Mechanism of Axon Outgrowth by Myelin Associated Inhibitors.
(2012)
Repair after injury to the adult mammalian central nervous system (CNS) is hindered by inhibitory proteins, including the myelin associated inhibitors (MAIs): NogoA, MAG, and OMgp. Blocking the function of MAIs and their ...
The Oxidative Modification of Mitochondrial Proteins in 1,3-Dinitrobenzene Induced Neurotoxicity.
(2009)
1,3-DNB has widespread use in industry and the military as a chemical intermediate in the development of various plastics, dyes, and explosives. As a result, the production and improper disposal of various DNB-containing ...
Developing Tools to Investigate Protein Sulfenylation in Living Cells.
(2011)
Oxidation of cysteine to sulfenic acid has emerged as a biologically relevant post-translational modification with particular importance in redox-mediated signal transduction; however, the identity of modified proteins ...
The Role of PALS1 in Mammalian Epithelial Polarity.
(2007)
Polarity is an intrinsic feature of epithelial cells, and it is reflected by the differential distribution of proteins and lipids in the apical and basolateral surfaces. The apical and basolateral membranes are separated ...
Characterization of Amyloid-B Interactions at the Membrane Interface: Implications for Pathogenesis. Implications for Pathogenesis.
(2009)
The 40 and 42 residue amyloid-β (Aβ) peptides are major components of the proteinaceous plaques prevalent in the Alzheimer’s disease afflicted brain and have been shown to play an important role in instigating neuronal ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Characterization of Human Hsp70 Chaperone Complexes and Chemical Control Over Their Formation.
(2012)
Heat shock protein 70 (Hsp70) is a molecular chaperone that plays a central role in cellular protein homeostasis by assisting in the folding and/or degradation of protein substrates. In these tasks, Hsp70 is assisted by ...
Structures of Exocyst Subunit Exo70 from Yeast and Mouse.
(2007)
Exocytosis is a eukaryotic process in which vesicles deliver membrane and other cargoes to and across the plasma membrane. The exocyst is a tethering complex necessary for the polarization and fusion of exocytic vesicles ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...