Now showing items 501-510 of 510
Characterization of the Amyloidogenic Peptides Amylin and PAP248-286.
(2012)
Many diseases in the aging population are associated with a class of peptide that aggregates to form amyloidogenic fibers through a misfolding from random coil, to cross β-sheet fibrils. Diseases such as Alzheimer’s disease, ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Characterization of the Dynamic Interactions of Transcriptional Activators
(2010)
Transcription is initiated through a series of coupled binding equilibria between transcriptional activators and their array of protein targets within the transcriptional machinery. However, previous efforts to kinetically ...
Transparent and Self-Healing Elastomers for Reconfigurable 3D Materials
(Wiley Periodicals, Inc., 2022-12)
Transparent soft materials are widely used in applications ranging from packaging to flexible displays, wearable devices, and optical lenses. Nevertheless, soft materials are susceptible to mechanical damage, leading to ...
Development of Structural and Synthetic Tools to Determine the Structure of the Active Ni(I) State of Methyl-Coenzyme M Reductase:Nature's Catalyst for Methane Synthesis, Activation, and Oxidation
(2023)
Methyl-Coenzyme M Reductase (MCR) catalyzes the forward and reverse reactions of methane biosynthesis and anaerobic methane oxidation, respectively. MCR employs radical chemistry via the catalytic Ni cofactor F430, where ...
Benzothiophene-based Fragments Act as Reversible and Irreversible Covalent Probes for Dynamic Coactivator Med25
(2023)
Transcriptional coactivators mediate transcriptional activity within cells by forming transient protein-protein interactions (PPIs) to facilitate the assembly of the RNA polymerase machinery. Dysregulation of these PPIs ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Exploring Novel Enzyme Activity and Genetic Diversity Through Biocatalytic Engineering and Microbiome Mapping
(2021)
Nature provides us with a wealth of natural product molecules and biological catalysts that represent a rich source of new life-saving pharmaceutical medicines and biotechnological tools for green chemistry. The synthetic ...