Now showing items 2041-2050 of 2090
Interactions between the Translation Machinery and a Translational preQ1 Riboswitch.
(2015)
Gene expression is highly regulated with a diversity of regulation at the RNA level. In bacteria, regulation of mRNA translation into protein often occurs through RNA sequence features such as the Shine-Dalgarno (SD) ...
Expanding the Arsenal: Development of G-Protein Receptor Kinase 5 Inhibitors Utilizing a Covalent Strategy
(2020)
Many cellular events are regulated by G-protein coupled receptors (GPCRs). In order to maintain homeostasis, GPCR kinases (GRKs) selectively recognize and phosphorylate activated GPCRs for internalization. There is growing ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Design and Characterization of Bifunctional Glucocorticoid Ligands Capable of Producing Novel Transcriptional Profiles.
(2015)
The process of transcription underlies the expression of all gene profiles. Normal expression is caused by carefully coordinating the assembly of transcriptional proteins at specific genes, a procedure mediated through ...
Molecular Basis for Selective Late-Stage Transformations in Fungal Indole Alkaloid Biosynthesis
(2019)
The class of fungal indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring is comprised of diverse molecules that display a range of biological activities. While much interest has been garnered due to their therapeutic ...
Structural Studies and Pharmacological Targeting of Protein Kinases in Obesity and Heart Disease
(2018)
Adrenergic receptors (AR) are G protein-coupled receptors (GPCRs) responsible for regulating physiological processes including the fight-or-flight response, muscle contraction, blood flow, and energy release. Numerous ...
Natural Product-Derived Lipopeptides Are Selective and Effective Modulators of the Coactivator Med25
(2022)
Transcription is an important cellular process that plays a vital role in the regulation of gene expression. A key component of this process is the protein-protein interactions (PPIs) that occur between transcriptional ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
Development and Application of Numerical Methods in Biomolecular Solvation
(2021)
This work addresses the development of fast summation methods for long range particle interactions and their application to problems in biomolecular solvation, which describes the interaction of proteins or other biomolecules ...
Genetic Incorporation of Unnatural Amino Acids for the Study of Protein-Protein Interactions.
(2016)
Proteins comprise the majority of the cell and are vital to all cellular functioning. Protein-protein interactions (PPIs) are the communication networks behind cellular processes, often functioning in machine-like complexes ...