Now showing items 161-169 of 169
Regulated expression of polysaccharide utilization and capsular biosynthesis loci in biofilm and planktonic Bacteroides thetaiotaomicron during growth in chemostats
(Wiley Periodicals, Inc., 2014-01)
Bacteroides thetaiotaomicron is a prominent member of the human distal gut microbiota that specializes in breaking down diet and host‐derived polysaccharides. While polysaccharide utilization has been well studied in B. ...
Mass transfer effects on microbial uptake of naphthalene from complex NAPLs
(Wiley Subscription Services, Inc., A Wiley Company, 1998-12-20)
The bioavailability of naphthalene present as a component of a complex nonaqueous phase liquid (NAPL) comprised by nine aromatic compounds was investigated. Specifically, the effects of naphthalene mass transfer from the ...
Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor
(Wiley Periodicals, Inc., 2019-11)
Breast cancer cells experience a range of shear stresses in the tumor microenvironment (TME). However most current in vitro three‐dimensional (3D) models fail to systematically probe the effects of this biophysical stimuli ...
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo
(Wiley Periodicals, Inc., 2020-01)
Metastases are preceded by stochastic formation of a hospitable microenvironment known as the premetastatic niche, which has been difficult to study. Herein, we employ implantable polycaprolactone scaffolds as an engineered ...
Large unit red cell cryopreservation with hydroxyethyl starch
(Elsevier, 1976-10)
Full units of red blood cells frozen with 14% hydroxyethyl starch (HES) yield cell recoveries near 97% and saline stabilities greater than 80%. Potassium leaves the cells during the freeze-thaw cycle and increases the ...
Computational Methods for Understanding Dynamics in Mass Transport and Tissue Development
(2020)
Elucidating the process by which a biological system evolves and properly identifying hidden states and influential underlying factors are important for studying biological functions and origins of diseases. However, due ...
Development and Application of Numerical Methods in Biomolecular Solvation
(2021)
This work addresses the development of fast summation methods for long range particle interactions and their application to problems in biomolecular solvation, which describes the interaction of proteins or other biomolecules ...
Exploring Drug Bioaccumulation and Stabilization with Respect to Endolysosomal Ion Homeostasis Using a Systems-Based Mathematical Modeling Approach
(2018)
Even though most of the FDA approved drugs currently out in the market and in the process of development are weakly basic drugs, the bioaccumulation and stabilization of these drugs are not well understood. For this purpose, ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...