Now showing items 2221-2230 of 2232
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase”
(Wiley Periodicals, Inc., 2022-11-14)
Manley and co-workers provide data demonstrating that, at super-pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP-competitive inhibitors is possible. The work in our manuscript ...
Unique Dimerization Topology and Countercation Binding Modes in 12-Metallacrown-4 Compounds
(Wiley-VCH Verlap & Co. KGaA, 2022-11-17)
Seven dimeric metallacrowns (MC) based on Ln[12-MCM(III)N(shi)-4], where LnIII=Dy, Ho, Yb, or Y, MIII=Mn or Ga, and shi3− is salicylhydroximate, have been synthesized and characterized by single-crystal X-ray diffraction, ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases
(Wiley Periodicals, Inc., 2023-05-08)
In the biosynthesis of the tryptophan-linked dimeric diketopiperazines (DKPs), cytochromes P450 selectively couple DKP monomers to generate a variety of intricate and isomeric frameworks. To determine the molecular basis ...
Demonstrating High Performing Thermophotovoltaic Systems Using Novel Cell-Side Architectures
(2024)
Thermophotovoltaic (TPV) generation is the conversion of thermal radiation to electrical power through the photovoltaic effect. This is a promising approach for various energy applications such as cogeneration of heat and ...
Mechanism of B-H Redistribution during Reduction of Polyborazylene by Hydrazine
(SpringerWiley Periodicals, Inc., 2023-06-13)
Density functional theory has been used to elucidate the mechanistic underpinnings of the regeneration of ammonia-borane (H3B−NH3, AB) from polyborazylene (BxNxHx, PBz) in the presence of hydrazine (H2N−NH2, Hz). Herein, ...
A Fluorescence Spectroscopic Approach to Studying Nanoparticle Chemical Environments, Architecture, and Assembly
(2024)
Three decades of intense research in nanomedicine have yielded few clinical outcomes, particularly in targeted gene delivery. Beyond regulatory challenges, the scarcity of FDA-approved nanoformulated gene therapies (only ...
Utilizing Polymer-Grafted, Anisotropic Nanoparticles for the Design of Novel Materials
(2024)
The range of available design elements to synthesize and functionalize nanoparticle building blocks that self-assemble into superlattice structures has increased drastically over the last 30 years. From the introduction ...