Now showing items 5011-5020 of 5054
3D Islet Assay Development and SAR of Chromenones for Beta-Cell Replenishment
(2023)
Diabetes poses a global health crisis affecting individuals across age groups and backgrounds, with a prevalence estimate of 700 million people worldwide by 2045. Current therapeutic strategies primarily rely on insulin ...
Charge and Proton Transport in Electrocatalysis by Polymer Encapsulated Cobalt Phthalocyanine
(2022)
The electrocatalytic CO2 reduction reaction (CO2RR) is one proposed method to convert industrial waste CO2 into value-added products using renewable electricity. There are many (photo)electrocatalysts that can decrease ...
Development of Nickel- and Palladium-Mediated Decarbonylative Coupling of Carboxylic Acid Derivatives: From Organometallic Reactivity to Catalysis
(2022)
Transition metal catalyzed cross coupling reactions are among the most widely used transformations in organic chemistry. While there has been tremendous work regarding aryl halide cross coupling, there has been growing ...
A Bidentate Ligand Featuring Ditopic Lewis Acids in the Second Sphere for Selective Substrate Capture and Activation
(Wiley Periodicals, Inc., 2023-03-20)
We present a ligand platform featuring appended ditopic Lewis acids to facilitate capture/activation of diatomic substrates. We show that incorporation of two 9-borabicyclo[3.3.1]nonane (9-BBN) units on a single carbon ...
Development of Group 10 Metal Catalyzed Decarbonylative Catalysis and Undergraduate Organic Chemistry 2 Lab Modules
(2022)
The development of novel methods to install fluoroalkyl groups into organic molecules is highly desirable due to the effects that fluorine atoms impart, such as metabolic stability and lipophilicity. Due to the commercial ...
Preparation and Functionalization of Mono- and Polyfluoroepoxides via Fluoroalkylation of Carbonyl Electrophiles
(Wiley, 2023-02-16)
We outline a new synthetic method to prepare mono- and polyfluoroepoxides from a diverse pool of electrophiles (ketones, acyl chlorides, esters) and fluoroalkyl anion equivalents. The initially formed α-fluoro alkoxides ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Molecular Rotational Correlation Times and Nanoviscosity Determined by 111mCd Perturbed Angular Correlation (PAC) of γ-rays Spectroscopy
(Wiley Periodicals, Inc.Springer, 2023-02-10)
The nanoviscosity experienced by molecules in solution may be determined through measurement of the molecular rotational correlation time, τc, for example, by fluorescence and NMR spectroscopy. With this work, we apply PAC ...
Biocatalytic P450 Oxidative Phenolic Coupling Reactions for Biaryl-bond Formation
(2022)
Atropisomers, derived from the Greek word “atropos,” meaning “without turn”, are chiral molecules that possess a bond that is sterically hindered, impeding free rotation around that bond. This structural feature impacts ...