Now showing items 561-570 of 578
Image Guided Respiratory Motion Analysis: Time Series and Image Registration.
(2008)
The efficacy of Image guided radiation therapy (IGRT) systems relies on accurately extracting, modeling and predicting tumor movement with imaging techniques. This thesis
investigates two key problems associated with such ...
Pooling Designs for High-Throughput Biological Experiments.
(2010)
High-throughput experiments provide a fast, automated way to obtain massive amounts of information about biological systems. In several instances, these experiments subject a large number of items (biological samples or ...
On Improving the Effectiveness of Control Signals from Chronic Microelectrodes for Cortical Neuroprostheses.
(2009)
Using microelectrodes, we can record neural signals which can eventually be used to control cortical neuroprostheses for assisting people with spinal-cord trauma, stroke deficits, amyotrophic lateral sclerosis (ALS), and ...
Medical Ultrasound Aberration Correction via Acoustic Droplet Vaporization and Time-Reversal Acoustics.
(2009)
Time-reversal acoustics (TRA) is an alternative to standard focusing approaches in medical ultrasound. TRA records backscattered ultrasound and time-reverses it (Ψ(t) -> Ψ(−t)). Due to the time-reversal invariance of the ...
Exploration and Exploitation of Action Selection in the Motor Cortex and Basal Ganglia.
(2010)
The basal ganglia (BG) have been proposed as a possible neural substrate for action selection in the vertebrate brain. In this thesis, I have focused on determining the role of BG circuits in selection of well-trained ...
Sarcomere Dynamics During Contraction-Induced Injury to Permeabilized Single Muscle Fibers.
(2008)
A contraction-induced injury results when an activated skeletal muscle or a single fiber is stretched in a ‘lengthening contraction’. This type of injury to muscle fibers is a leading cause of the loss of mobility that is ...
An Alternative Outpatient Scheduling System: Improving the Outpatient Experience.
(2008)
Patient wait time has long been a recognized problem in modern outpatient health care delivery systems. Despite all the efforts to develop appointment rules and solutions, the problem of long patient waits persists. ...
Automated Natural-Language Processing for Integration and Functional Annotation of Complex Biological Systems.
(2008)
This dissertation discusses the use of automated natural language processing (NLP) for characterization of biomolecular events in signal transduction pathway databases. I also discuss the use of a dynamic map engine for ...
Novel Bioinformatics Approaches for MicroRNA Detection and Target Prediction.
(2009)
MicroRNAs (miRNAs) are regulators of gene expression at the post-transcriptional level. Scientists have not been able to fully unlock their therapeutic potential because their functions and mechanisms of action have not ...
Raman Spectroscopy Detection of Molecular Changes Associated with Osteoarthritis.
(2009)
Vibrational spectroscopic methods are minimally invasive, and are appropriate for use in clinical contexts. Methods were developed in this dissertation for evaluating joint damage and disease using Raman spectroscopy. ...