Now showing items 191-199 of 199
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Ultrasound-triggered Drug Delivery Using Acoustic Droplet Vaporization.
(2010)
The goal of targeted drug delivery is the spatial and temporal localization of a therapeutic agent and its associated bioeffects. One method of drug localization is acoustic droplet vaporization (ADV), whereby drug-laden ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Design and Evaluation of Elastic Exoskeletons for Human Running
(2010)
Humans bounce along the ground when they hop and run, providing spring-like function with their muscles and tendons. Compliant elastic mechanisms could assist this motion by contributing additional elastic storage and ...
Pooling Designs for High-Throughput Biological Experiments.
(2010)
High-throughput experiments provide a fast, automated way to obtain massive amounts of information about biological systems. In several instances, these experiments subject a large number of items (biological samples or ...
Exploration and Exploitation of Action Selection in the Motor Cortex and Basal Ganglia.
(2010)
The basal ganglia (BG) have been proposed as a possible neural substrate for action selection in the vertebrate brain. In this thesis, I have focused on determining the role of BG circuits in selection of well-trained ...
Memory, Interference and Depression.
(2010)
This dissertation explores the role of interference in short-term memory and how interference in memory may influence depression. The first chapter tackles whether forgetting in the short-term is due to decay with the ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Engineering the Quantitative PCR Assay for Decreased Cost and Complexity.
(2011)
The quantitative polymerase chain reaction (qPCR) is an assay of target nucleic acid concentration. Clinical applications of quantitative PCR include measurement of HIV viral load, measurement of bacterial infection, and ...