Now showing items 101-110 of 133
Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05)
This article extends the Patient Rule-Induction Method (PRIM) for modeling cumulative incidence of disease developed by Dyson et al. (Genet Epidemiol 31:515–527) to include the simultaneous consideration of non-additive ...
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [:2003 Nature 426:789–796]. A key goal of the HapMap Project is to enable ...
Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep
(Wiley Periodicals, Inc., 2017-01)
Using PepExplorer to Filter and Organize De Novo Peptide Sequencing Results
(Wiley Periodicals, Inc.Humana Press, 2015-09)
PepExplorer aids in the biological interpretation of de novo sequencing results; this is accomplished by assembling a list of homolog proteins obtained by aligning results from widely adopted de novo sequencing tools against ...
Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses
(John Wiley & Sons, Ltd., 2002-09)
Background Helper-dependent, or gutted, adenoviruses (Ad) lack viral coding sequences, resulting in reduced immunotoxicity compared with conventional Ad vectors. Gutted Ad growth requires a conventional Ad to supply ...
Lipopolysaccharide recognition protein, MD-2, facilitates cellular uptake of E. coli -derived plasmid DNA in synovium
(John Wiley & Sons, Ltd., 2005-07)
Background Several cell types are susceptible to transfection in vivo using naked plasmid DNA. The mechanisms involved in mediating in vivo transfection are incompletely known, but evidence suggests that receptor-mediated ...
An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
(Wiley Subscription Services, Inc., A Wiley Company, 2007-09)
Different combinations of genetic and environmental risk factors are known to contribute to the complex etiology of ischemic heart disease (IHD) in different subsets of individuals. We employed the Patient Rule-Induction ...
Identifying Rare Variants Associated with Complex Traits via Sequencing
(Chapman and HallWiley Periodicals, Inc., 2013-07)
Although genome‐wide association studies have been successful in detecting associations with common variants, there is currently an increasing interest in identifying low‐frequency and rare variants associated with complex ...
Methods for Association Analysis and Meta‐Analysis of Rare Variants in Families
(Wiley Periodicals, Inc.Springer‐Verlag, 2015-05)
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety ...
Genome‐wide survey in African Americans demonstrates potential epistasis of fitness in the human genome
(Wiley Periodicals, Inc.Sinauer Associates, 2017-02)
The role played by epistasis between alleles at unlinked loci in shaping population fitness has been debated for many years and the existing evidence has been mainly accumulated from model organisms. In model organisms, ...