Now showing items 35261-35270 of 37299
Context-Dependent Interaction of the Androgen Receptor with Oncogenic Pathways Common to Prostate Cancer.
(2015)
Androgen receptor (AR) is a hormone-responsive transcription factor central to prostate cancer (PCa) onset and progression. Therapies targeting AR signaling are initially successful, yet acquired resistance is a major ...
The Intersection of Early Life Experiences and Serotonergic Gene Expression on Behavior and Physiology.
(2013)
Adverse early life experiences (aELEs), such as childhood abuse, neglect, or trauma, increase lifetime vulnerability for mental illness. Interactions between aELEs and polymorphisms in serotonergic (5-HT) genes can further ...
Novel Flexible Statistical Methods for Missing Data Problems and Personalized Health Care
(2019)
Coarsened data, including a broad class of incomplete data structures, are ubiquitous in biomedical research. Various methods have been proposed when data are coarsened at random, where it is often required to specify ...
The Interplay of Lipoproteins and Innate Immune Responses in Systemic Lupus Erythematosus and its Role in Premature Cardiovascular Disease.
(2015)
Systemic lupus erythematosus (SLE) is an autoimmune syndrome that primarily affects women and leads to significant internal organ damage. Patients with SLE exhibit a high risk for premature atherosclerotic cardiovascular ...
Social Capital and Health in the Developing World: Meaning, Mechanisms, and Measurement
(2013)
The overall goal of this dissertation is to contribute to the understanding of community-based development by exploring the relationship between social capital and health in the developing world. Distinct methodological ...
Statistical Learning for Large-Scale and Complex-Structured Data
(2022)
Our modern era has seen an explosion in the amount of valuable information stored in large and complex datasets. The growing scale, diversity of data structures, and incomplete observations in these datasets pose new ...
Sexually Transmitted Diseases Among Pastoralists in Kaokoland, Namibia: Epidemiology, Ecology and Behavior.
(2012)
The pastoralist communities in Kaokoland, Namibia, have long been presumed to have high prevalence of sexually transmitted diseases (STDs) and associated morbidities. Though their geographic remoteness makes access to ...
Development Of An Artificial Membrane Lung
(2016)
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of death across the world. However, treatment options for end-stage COPD are extremely limited. An artificial membrane lung ...
The Role of Discoidin Domain Receptor 2 in Bone Regeneration
(2019)
Bone is a dynamic tissue with self-healing capabilities that allow repair of most fractures with restoration of original architecture. However, large bone defects, such as those caused by tumor resections or severe trauma, ...
Secondhand Smoke Exposure and Adverse Asthma Events Among Low-Income Michigan Children
(2018)
More than eight percent of United States’ children have asthma, with more than half having an asthma exacerbation annually. Minority children and those living in low income households are more likely to experience adverse ...