Now showing items 35281-35290 of 37271
Structural and Biochemical Analysis of G Protein-Coupled Receptor Kinase Activation and Small Molecule Inhibitor Selectivity
(2019)
Cellular signaling through G protein-coupled receptors (GPCRs) is essential for most physiological processes, ranging from vision, taste, and smell to immune, neurological, and cardiovascular functions. In order to remain ...
Targeting Sigma-2 Receptor and ZFP91 in Pancreatic Cancer
(2021)
Pancreatic cancer is one of the most aggressive malignancies with poor prognosis. The effectiveness of currently available conventional therapies is limited by chemoresistance and systemic toxicity. Thus, there is an urgent ...
Inference of Infectious Disease Dynamics from Genetic Data via Sequential Monte Carlo
(2018)
When an epidemic moves through a population of hosts, the process of transmission may leave a signature in the genetic sequences of the pathogen. Patterns in pathogen sequences may therefore be a rich source of information ...
Noninvasive Electrical Neuroimaging of the Human Brain during Mobile Tasks including Walking and Running.
(2012)
Noninvasive brain imaging during mobile activities could have far reaching scientific, clinical, and technological benefits. Electroencephalography (EEG) is the only mobile noninvasive sensing modality with sufficient ...
Low-Flow Push-Pull Perfusion for Measuring Neurotransmitters with High Spatial and Temporal Resolution within the Living Brain.
(2013)
Low-flow push-pull perfusion is a technique for measuring neurotransmitters within the brain with ~200 μm resolution. Activity of neurotransmitters can vary on this size scale; therefore, low-flow push-pull may offer new ...
The Influence of Breast Reconstruction Choice on Functional Shoulder Biomechanics in Women Undergoing Mastectomy for Breast Cancer
(2020)
A majority of women that undergo mastectomy for breast cancer will choose to have reconstructive surgery performed to return the look and feel of healthy breast tissue. Common breast reconstruction techniques remove the ...
Improved Mitochondrial Stress Response in Long-lived Snell Dwarf Mice
(2018)
Upregulation of the mitochondrial unfolded protein response (mtUPR) as a result of alterations in mitochondrial protein stoichiometry has been proposed as a common pathway in longevity. While mtUPR upregulation correlates ...
Dynamic Control of Network Level Information Processing through Cholinergic Modulation
(2018)
Acetylcholine (ACh) release is a prominent neurochemical marker of arousal state
within the brain. Changes in ACh are associated with changes in neural activity and
information processing, though its exact role and the ...
Investigating Endothelial Dysfunction in a CRISPR/Cas9 Model of Fabry Disease
(2017)
Fabry disease is a rare, X-linked lysosomal storage disease arising from deficiency of the lysosomal hydrolase, α-galactosidase A (GLA). Reduced GLA activity disrupts glycosphingolipid (GSL) catabolism, leading to widespread ...
Methods for Clustered Competing Risks Data and Causal Inference using Instrumental Variables for Censored Time-to-event Data
(2018)
In this dissertation, we propose new methods for analysis of clustered competing risks data (Chapters 1 and 2) and for instrumental variable (IV) analysis of univariate censored time-to-event data and competing risks data ...