Now showing items 35291-35300 of 37299
Modeling of Infectious Disease Informed by Investigative Focus and Data Characteristics, From the Microscopic to County Community Level
(2022)
Infectious disease modeling is a tool to understand disease characteristics of interest, which is often used to make predictions and guide public health policy. These models rely heavily on observational data, which greatly ...
Discovery and Development of Small Molecule Probes for the SUMO protease SENP1, a Novel Target for Advanced Prostate Cancer Therapy
(2017)
Androgen signaling through the androgen receptor (AR) is essential for normal growth and function of the prostate gland. In prostate cancer (PC), androgens provide the main proliferative drive for the disease, making ...
Cocaine Esterase: A pharmacokinetic approach to treating cocaine addiction
(2017)
Cocaine’s impact on society spans several thousand years, yet its adverse effects due to the toll of addiction have only imposed a global problem during the last hundred years. After cocaine was isolated from its natural ...
Role of the Cochlear Nucleus Circuitry in Tinnitus and Hyperacusis
(2020)
Tinnitus is the disorder of phantom sound perception, while hyperacusis is abnormally increased loudness growth. Tinnitus and hyperacusis are both associated with hearing loss, but hearing loss does not always occur with ...
Two Biostatistical Problems
(2023)
This dissertation examines two problems in biostatistics. The first and second projects develop horseshoe process regression (HPR), a Bayesian nonparametric model that uses statistical shrinkage to capture abruptly changing ...
Evaluating Neighborhood Environments for Urban Heat Island Analysis and Reduction.
(2013)
City officials are increasingly concerned about heat. Two warming processes are increasing the occurrence of urban heat: 1) global warming caused by greenhouse gas emissions and 2) intensifying urban heat islands (UHI) ...
Protection from Stroke through Immunomodulatory Mechanisms.
(2014)
Ischemic stroke is a leading cause of morbidity and mortality in the world, and inflammation can have a significant impact on stroke severity. Sustained inflammation after stroke can have detrimental effects; however, ...
Oscillations of the Granular Retrosplenial Cortex
(2021)
The retrosplenial cortex is essential for spatial memory and navigation. We sought to learn about how the retrosplenial cortex encodes information through oscillations. Our experiment results reveal an oscillation pattern ...
Development and Pathology of the Mammalian Pylorus.
(2015)
The pylorus is the junction between the stomach and the small intestine. It regulates food movement between the two organs and prevents the regurgitation of duodenal contents into the stomach. An evolutionarily conserved ...
Metabolomics: A Promising Tool to Improve the Understanding of the Developmental Origins of Obesity and Metabolic Disease.
(2019)
The prevalence of obesity and type 2 diabetes continues to rise in the pediatric and adult population. This increase in metabolic disease may be partially due to programming during sensitive periods of development. ...