Now showing items 35301-35310 of 37299
Effects of Exercise and Elevated Fatty Acid Availability on Muscle Lipid Metabolism and Insulin Sensitivity.
(2012)
Elevated systemic fatty acid availability is a key factor underlying obesity-related insulin resistance and type 2 diabetes. A single session of exercise can protect against fatty acid-induced insulin resistance, possibly ...
Pharmacology of Hsp70 Activation
(2020)
The heat shock protein 90 and 70 (Hsp90 and Hsp70) chaperone system maintains protein quality control for over one hundred client proteins, including many implicated in neurodegenerative disorders, by surveilling substrate ...
Modern Slavery: Violence, Coercion and Mental Health of Female and Male Trafficking Survivors in the Mekong Sub-region: Cambodia, Thailand, and Vietnam
(2018)
Background: Human trafficking is a crime and a violation of fundamental human rights that affects 40.3 million people worldwide. The Asia Pacific region accounts for the largest number of forced laborers including children, ...
Computational Approaches Enabling Disparately Acquired Untargeted LC-MS Metabolomics Data Analysis
(2022)
Metabolomics is the systematic study of small molecule metabolites that are substrates, intermediates, and products of cellular metabolism. Metabolomics assays performed using liquid chromatography- mass spectrometry (LC-MS) ...
Cross-Sector Care Activities and Technological Capabilities of Federally Qualified Health Centers in Michigan
(2023)
Health systems and medical practices are taking a greater role in providing social care. Federally Qualified Health Centers (FQHCs) lead these efforts, offering a model for using technology to manage care and exchange ...
Statistical Methods for Analyzing Population-scale Genomic and Transcriptomic Data
(2021)
The study of genetics is an integral part to understanding the biology behind our complex traits and can be approached in a variety of ways. Technological advancements in the field of genomics have enabled unprecedented ...
The Role of the YEATS Epigenetic Reader in MLL-r Fusion Proteins
(2023)
MLL (KMT2a) translocations are found in ~10% of acute leukemia patients, giving rise to an aggressive subset of leukemias. The majority of MLL fusion partners are members of epigenetic and transcriptional regulatory ...
Development of Selective -Opioid Receptor Positive Allosteric Modulators for the Treatment of Depression
(2023)
Major depressive disorder is one of the three leading causes that reduce quality of life. Due to the comorbidity of major depressive disorder with anxiety and chronic pain, existing antidepressant drugs have limited ...
The Dynamic Nature of the POMC Neuron Landscape, and the Impact of POMC Peptides and Body Composition States in Motivated Feeding
(2019)
The importance of proopiomelanocortin (POMC) in maintaining normal metabolic homeostasis is well established. However, due to the phenotypes associated with human-patients and animal models with dysfunctional melanocortin ...
Occupational Health in Academic Research Laboratories: Upstream Factors of Risk
(2020)
High profile injuries and fatalities in academic research laboratories have placed academic research safety culture in the spotlight. Academic research is a high-cost, high-risk investment of over 75 billion federal dollars ...