Now showing items 35311-35320 of 37301
Improved Analysis of Large Genetic Association Studies Using Summary Statistics
(2018)
Genome-wide association studies, which examine millions of genetic variants in thousands of individuals, have identified many complex trait associated loci. As sample sizes increase, particularly through meta-analysis, the ...
The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease Development
(2019)
This dissertation is a culmination of several projects that each explore how early-life diet or drug can impact later-life health outcomes. The first chapter is an introduction to provide important context or supplementary ...
Neural Mechanisms Underlying Attention Deficits in Posttraumatic Stress Disorder
(2018)
OBJECTIVE: Post-traumatic stress disorder (PTSD) is associated with altered attentional performance and functional connectivity in intrinsic connectivity networks (ICNs) related to attention. There is conflicting research ...
Stress Biomarkers and Latinos' Exposure to the United States.
(2016)
Background: Latino immigrants to the United States (US) have better health and mortality outcomes than US-born Latinos, but this health advantage erodes with increasing duration of US residence. Public health scholars have ...
An Examination of Physical Activity and Motor Competence in Parents and Children
(2021)
Both parents’ and children’s physical activity levels are extremely low in the United States, with documented adverse consequences on physical and mental health status. One potential contributing factor to low physical ...
A Dissertation on Sustainability Competence: Directions for Nursing
(2020)
Human health and wellbeing are rooted in the environment, and thus are threatened by environmental degradation. The healthcare industry, as the largest sector of the economy by volume and workforce, is a significant ...
The Role of NELF in Mediating Human Gene Expression
(2017)
Transcription is the synthesis of RNA from a DNA template. Transcription has been shown to occur in three main steps, initiation, elongation and termination. Additional regulatory steps include a rate limiting step between ...
Optimizing Post-Stroke Functioning: Using Mixed Methods to Understand the Role of Built and Social Environments for Physical Activity, Quality of Life, and Lived Experience
(2021)
An estimated 6.6 million Americans over age 20 have experienced a stroke, making it a leading cause of serious long-term disability in the United States. Medical advances in treatment of acute stroke and an aging population ...
Oxazaphosphorine Metabolism by the Human Cytochrome P450s and Some Commonly Expressed P450 Polymorphic Variants.
(2013)
The oxazaphosphorines, cyclophosphamide (CPA) and ifosfamide (IFO), are commonly used cancer therapeutics. Hallmarks of oxazaphosphorine-treatment include variable patient response and severe adverse drug reactions. These ...
(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan.
(2012)
Chapter 1: We evaluated the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan ...