Now showing items 1401-1410 of 1412
The Role of Transcription Factor EB in the Vascular Wall Biology
(2019)
Transcription factor EB (TFEB) is a member of the microphthalmia transcription factor family, with adjacent basic helix-loop-helix and leucine zipper domains. Among them, TFEB has been found to be a master regulator of ...
Understanding the Biology of Triple Negative Breast Cancer and Breast Cancer Stem Cells in Patients of Diverse Ethnicities
(2017)
Triple negative breast cancer is one of the most aggressive breast cancer subtypes, for which there are no approved targeted therapies. In US alone, the incidence of TNBC is highest in women with African ancestry (AA); in ...
Using a Massive Open Online Course Format to Engage Health Professions Students Regarding Health Systems Science and the U.S. Healthcare System
(2019)
As the U.S. healthcare system undergoes significant transformation, providers who have been traditionally viewed as the nexus of care delivery inside the healthcare system, are struggling to effectively participate in ...
Investigating the Role of AGO2-RAS Interaction in Mutant RAS Driven Cancers
(2022)
The RAS genes are among the most commonly mutated genes in cancer. These genes code for GTPases that act as growth factor receptor-regulated molecular switches. Mutations in RAS lead to a loss in GTP hydrolysis and cause ...
Investigating the HIV Reservoir in Hematopoietic Stem and Progenitor Cells
(2018)
Current antiretroviral therapies are not curative because they do not eradicate long-lived cells harboring HIV proviral DNA and thus, if a patient stops therapy, circulating virus will rebound. A subset of hematopoietic ...
Cognitive Function, Self-care, and Glycemic Control in Rural Adults with Type 2 Diabetes
(2017)
Cognitive Function, Self-Care, and Glycemic Control in Rural Adults with Type 2 Diabetes
Abstract
The prevalence of type 2 diabetes mellitus (DM) has increased dramatically over the past two decades, particularly among ...
In Search of New Perspectives in Cancer Genetics Services: Exploring Use of Genetic Counseling Among a Group of Young Breast Cancer Survivors
(2018)
Breast cancer associated with mutations in the breast cancer genes BRCA1 and BRCA2 often occurs at an earlier age and individuals with a mutation have increased risk for developing breast, ovarian, and other cancers. The ...
Three Essays on the Economics of Consumerism in Health Policy
(2019)
Consumerism, the notion of giving people the ability and responsibility to make choices about cost and quality, is an increasingly popular strategy to contain health spending. Yet we lack robust knowledge about how recent ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Efficacy and safety of vibegron for the treatment of irritable bowel syndrome in women: Results of a randomized, double-blind, placebo-controlled phase 2 trial
(Urovant Sciences, IncWiley Periodicals, Inc., 2022-12)
BackgroundPreclinical and clinical studies suggest that β3-adrenergic receptor activation may be a novel target for treating abdominal pain and gastrointestinal motility dysfunction in patients with irritable bowel syndrome ...