Now showing items 2951-2956 of 2956
Identifying Altered Metabolic Signatures in Septic Shock: Steps Toward Precision Pharmacotherapy
(2023)
Sepsis is a life-threatening clinical syndrome characterized by a dysregulated host-response to infection and organ dysfunction. There are variable clinical course trajectories in patients with sepsis, and the precise ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Efficacy and safety of vibegron for the treatment of irritable bowel syndrome in women: Results of a randomized, double-blind, placebo-controlled phase 2 trial
(Urovant Sciences, IncWiley Periodicals, Inc., 2022-12)
BackgroundPreclinical and clinical studies suggest that β3-adrenergic receptor activation may be a novel target for treating abdominal pain and gastrointestinal motility dysfunction in patients with irritable bowel syndrome ...
Effect of chronic mucus hypersecretion on treatment responses to inhaled therapies in patients with chronic obstructive pulmonary disease: Post hoc analysis of the IMPACT trial
(John Wiley & Sons, Ltd, 2022-12)
Background and objectiveChronic mucus hypersecretion (CMH) is a clinical phenotype of COPD. This exploratory post hoc analysis assessed relationship between CMH status and treatment response in IMPACT.MethodsPatients were ...
Association of prior local therapy and outcomes with programmed-death ligand-1 inhibitors in advanced urothelial cancer
(Wiley Periodicals, Inc., 2022-11)
Development and Validation of Transportable, Clinically Applicable and Scalable Machine Learning Models for Acute Kidney Injury
(2024)
Acute kidney injury (AKI), a frequent complication in hospitalized patients, poses significant challenges due to its high incidence, short-term mortality, and substantial economic burden. Current AKI models utilizing ...