Now showing items 2971-2980 of 3002
Targeting the Hsp90 Molecular Chaperone and Resistant Pathways in BRAF-mutant Melanoma
(2020)
Melanoma remains the most aggressive and fatal type of skin cancer. In greater than 50% of cases, patients present with an activating BRAF mutation (BRAF+), leading to upregulated mitogen-activated protein kinase (MAPK) ...
Designing System Support for Sharing Everyday Data for Chronic Care
(2022)
The prevalence of chronic conditions has shifted care settings into private homes. In addition, the increasing availability of physical- and algorithmic-sensing solutions promises large quantities of data about one’s ...
Urinary Continence Recovery After Radical Prostatectomy Using Patient Reported Outcomes Data: Variability, Predictions, and Prediction Accuracy
(2022)
Despite advances in prostate cancer treatment, wide variability in post-operative oncologic and functional outcomes are observed. Effective management of prostate cancer requires accurate prediction of potential outcomes ...
Multiple Chronic Conditions and Post-Stroke Functional Outcome
(2020)
Stroke is a leading cause of disability in the United States (US) and the number of disabled stroke survivors will rise with the aging population. The aging of the US population will also lead to an increase in the prevalence ...
Development Of An Artificial Membrane Lung
(2016)
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of death across the world. However, treatment options for end-stage COPD are extremely limited. An artificial membrane lung ...
The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology Approach
(2018)
ASH1L (absent, small, or homeotic-like 1) is a histone lysine methyltransferase (KMTase) that is overexpressed in cancer and activates oncogenic HOX genes. Small molecule inhibitors of ASH1L would be invaluable tools to ...
Knee Osteoarthritis: Intersections of Obesity, Inflammation, and Metabolic Dysfunction.
(2012)
Background: Obesity is a risk factor for osteoarthritis (OA) and may impart joint-damaging effects through dysfunctional metabolic mechanisms associated with increased adipose tissue.
Objective: To evaluate the relationship ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Receptor Regulation of Volume-Sensitive Osmolyte Efflux from Neural Cells.
(2007)
Cell volume regulation is a homeostatic imperative in the brain due to the restrictions of the skull. To counteract an osmolarity disturbance and restore normal cell volume, neural cells initiate volume regulatory mechanism ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...