Now showing items 1181-1190 of 1250
The Molecular Underpinnings and Regulation of Amino Acid Pathways in Ewing sarcoma
(2022)
Ewing sarcoma is an aggressive pediatric bone and soft tissue tumor, most commonly driven by EWS-FLI1. The standard of care for Ewing sarcoma has not improved in decades, and by far the best predictor of poor prognosis is ...
Membrane Trafficking and Signaling of the Delta Opioid Receptor Within the Biosynthetic Pathway
(2022)
G protein-coupled receptors (GPCRs) transduce diverse signals, including light, ions, hormones, and neurotransmitters, into equally diverse cellular responses. These cellular responses underlie complex physiological ...
Regulation of Opioid Receptor Trafficking and Signaling by Opioid Peptides
(2021)
All opioids - whether they are addictive opioid analgesics or endogenous opioids
like endorphins produced by our body - activate one of three receptors in our brain.
However, different opioids cause different effects, ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
Molecular Basis of Inhibitory Modulation of P2X2 Receptors by Zinc and Copper.
(2012)
P2X receptors are ion channels gated by ATP and modulated by the trace metals zinc and copper. Rat P2X2 (rP2X2) receptors show potentiation in the presence of a submaximal concentration of ATP but are inhibited by zinc at ...
Investigating the HIV Reservoir in Hematopoietic Stem and Progenitor Cells
(2018)
Current antiretroviral therapies are not curative because they do not eradicate long-lived cells harboring HIV proviral DNA and thus, if a patient stops therapy, circulating virus will rebound. A subset of hematopoietic ...
Discovery and Characterization of Non-Coding RNAs with Therapeutic and Diagnostic Potential in Prostate Cancer
(2019)
Prostate cancer is the most common malignancy and the second leading cause of death in American men. Primary prostate cancer is often hormone-dependent and relies on signaling through the androgen receptor (AR); therefore, ...
Novel Mechanisms that Antagonize Hedgehog Signaling at the Cell Surface During Vertebrate Embryogenesis
(2017)
Hedgehog (HH) signaling is a conserved mode of cell-cell communication that is indispensible for embryogenesis. HH proteins are secreted ligands that travel over long distances within a developing tissue to induce distinct ...
Investigating the Proliferation-Quiescence Decision in Tissues and in Cancer Cells
(2022)
Tight regulation of cell division is important for proper development and homeostasis in all multicellular organisms. While most cells in an adult metazoan exit cell cycle and exist in a non-dividing or quiescent state, a ...
The Role of Hypoxia-Inducible Factors in the Regulation of Systemic Iron Homeostasis.
(2013)
Disorders of Iron Homeostasis affect over a billion people worldwide. These disorders can be grouped according to iron deficiency, the major cause of anemia, and iron overload, the major cause of death in patients with ...