Now showing items 1241-1250 of 1250
Role of GLUT1 in the Mammalian Target of Rapamycin Pathway: Mechanisms of Regulation.
(2010)
GLUT1-mediated glucose transport is a highly regulated process and is dependent on a variety of signaling events. The glycogen synthase kinase (GSK)-3/tuberous sclerosis(TSC)/mammalian target of rapamycin (mTOR) signaling ...
Effects of In Vivo Exercise and In Vitro Contractile Activity on the Regulation of AS160, TBC1D1 and Glucose Transport in Rat Skeletal Muscle.
(2010)
A single bout of exercise leads to an increase in insulin-independent and insulin-dependent increase in glucose transport (GT). Phosphorylation of two members of the TBC1 (tre-2/USP6, BUB2, cdc16) domain family of proteins, ...
Mechanisms of MLL Fusion Protein-Mediated Leukemic Transformation.
(2010)
Leukemogenic MLL fusion proteins, including MLL-AF4, MLL-AF9, and MLL-ENL, transform through up regulated expression of HOX genes and the HOX cofactor MEIS1. How they lead to the aberrant activation of these genes is not ...
Analysis of the Molecular Mechanism of Autophagosome Formation in the Yeast Saccharomyces Cerevisiae.
(2010)
As a lysosomal/vacuolar degradative pathway conserved in eukaryotic organisms, autophagy mediates the turnover of long-lived proteins and excess or aberrant organelles. During autophagy, a double-membrane vesicle, the ...
Endothelial Cell - Stem Cell Crosstalk in Head and Neck Cancer.
(2011)
Head and neck squamous cell carcinomas contain a sub-population of highly tumorigenic cells that exhibit self-renewal and multipotency. These cells can be isolated from primary head and neck squamous cell carcinomas using ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Oral biofilm dysbiosis during experimental periodontitis
(Wiley Periodicals, Inc., 2022-12)
ObjectivesWe have previously characterized the main osteoimmunological events that occur during ligature periodontitis. This study aims to determine the polymicrobial community shifts that occur during disease developmen ...
Mimicking partial to total placental insufficiency in a rabbit model of cerebral palsy
(Springer International PublishingWiley Periodicals, Inc., 2022-12)
All placental abruptions begin as partial abruptions, which sometimes manifest as fetal bradycardia. The progression from partial to total abruption was mimicked by a new rabbit model of placental insufficiency, and we ...
Mechanisms of skeletal muscle repair and regeneration in health and disease
(Wiley Periodicals, Inc., 2022-11)
The Role of Mechanosensitive Calcium Signaling in Remodeling of Epithelial Cell-Cell Junctions
(2021)
Epithelial cells line most of our body cavities, separating different compartments in our bodies, creating selective barriers, and protecting us from external pathogens. In epithelial tissues, cells experience a range of ...