Now showing items 1191-1200 of 1252
Spatial and Temporal Protein Oxidation and Redox Signaling in Mechanisms of Structural Birth Defects
(2021)
Neural tube defects (NTDs) are birth defects that arise from failed neural tube closure resulting in morphological abnormality of the brain and spinal cord. NTD risk has been associated with genetic mutations, a maternal ...
How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity
(2020)
Our ability to taste sugar evolved to tell us that certain foods are good to eat because they provide us with energy. However, in the modern food environment of ubiquitous “added sugars”, this good taste can be hijacked ...
Regulation of mTOR Complexes in Long-Lived Growth Hormone Receptor Knockout and Snell Dwarf Mice
(2022)
mTOR is a serine/threonine kinase that binds with multiple proteins to form two complexes, mTORC1 and mTORC2. mTORC1 receives upstream signals including amino acids, growth factors, energy and oxygen levels to regulate ...
Mechanisms of Plasma Membrane Repair in Striated Muscle
(2020)
Sarcolemma instability is a hallmark of multiple types of muscular dystrophy and is typically caused by two major pathological mechanisms: increased susceptibility of the sarcolemma to contraction-induced damage or decreased ...
Investigation of Epithelial Cell Fate Decisions in the Developing Human Lung Guides the Generation of Human Lung Organoid Model Systems
(2019)
1 in 10 U.S. infants are born prematurely (www.cdc.gov), before the lungs have fully formed. The primary cause of mortality in these patients is underdeveloped lungs, but even surviving patients have a 40% chance of ...
Analysis of Long Range Gene Regulation in Drosophila; Insights from the dPax2 sparking Enhancer.
(2012)
Enhancers, a subclass of cis-regulatory sequences control gene expression and patterning during development. As enhancers are often located at considerable genomic distances from their target genes, distal enhancer promoter ...
Investigating Molecular Mechanisms of Drug Resistance in a 3D Cell Culture Model of Pancreatic Cancer
(2019)
Pancreatic cancer is the fourth leading cause of malignancy-related mortality in the United States. Despite decades of intensive research, patient 5-year survival following diagnosis remains below 10%. The high mortality ...
Computational Methods to Dissect Tissue-Specific Landscapes of Transcription Factor and DNA Interactions
(2020)
The intricately ordered structure of the human genome is a product of dynamic interactions between DNA and proteins such as nucleosomes and transcription factors (TFs), which allow cells to respond to environmental changes ...
The Role of Long Noncoding RNA SChLAP1 in Prostate Cancer
(2017)
Prostate cancer is the most common malignancy in U.S. men, accounting for nearly 30,000 deaths annually. While the majority of prostate cancers are indolent, a subset of patients has aggressive disease. However, the molecular ...
Symmetric Neural Progenitor Divisions Require Chromatin-Mediated Homology-Directed DNA Repair
(2021)
The cerebral cortex is generated by a highly coordinated series of cellular proliferations, beginning with symmetric neural progenitor cell (NPC) divisions to expand the pool of progenitors, and subsequent asymmetric NPC ...