Now showing items 1201-1210 of 1250
Investigating the Cell-Autonomous Role of Autophagy in Colon Cancer and the Reliance of Mitophagy for Growth
(2019)
Colorectal cancer (CRC) is the third leading cause of cancer related deaths
worldwide. Cancer cells modify normal cell functions to adapt to the surrounding tumor
microenvironment. Autophagy is a basic cell function used ...
An Investigation of the RNA Induced Silencing Complex and its Therapeutic Implications.
(2013)
Small interfering RNAs (siRNAs) are regulatory non-coding RNA, which regulate gene expression at the post-transcriptional level through the highly conserved RNA interference (RNAi) pathway. RNAi is employed by most eukaryotes ...
Elucidation of DNA-Binding and Dimerization Activities of the Master Virulence Transcription Factor, VirF, From Shigella flexneri to Aid in Virulence-Targeted Inhibitor Design for Treatment of Shigellosis
(2022)
The uncontrollable rise in resistance to current antimicrobial agents is a worldwide concern. Beyond traditional approaches to develop novel antibiotics, targeting bacterial virulence is considered a promising approach. ...
Regulation of Adipose Tissue Function and Metabolic Homeostasis.
(2014)
Metabolic syndrome is emerging as a global epidemic that increases the risk for type 2 diabetes, cardiovascular disease, and fatty liver disease. Brown and white adipose tissues carry out diverse metabolic functions and ...
Engineering Platforms for Mimicking Cellular Processes using Cell-Free Expression Systems
(2020)
Bottom-up in vitro reconstitution has provided fundamental insights into the mechanisms of key cellular processes. Traditional reconstitution methods rely on protein purification as the primary means of extracting functional ...
The Drosophila Male Germline During DNA Damage and Aging
(2020)
Evolution is thought to drive the progression of populations, conferring advantages through alterations in structure and form. However, the corollary to this theory would dictate that the things that do not change, those ...
Autophagy and Cell-Autonomy in Mouse Models of PI(3,5)P2 Deficiency
(2013)
FIG4 is the 5-phosphatase required for synthesis and turnover of the membrane signaling lipid PI(3,5)P2 (phosphatidylinositol-(3,5)-bisphosphate). Mutation of Fig4 causes neurodegeneration in mice and the neuropathy ...
Dynamics and Regulation of Cytoskeletal Proteins
(2019)
In this dissertation, I apply molecular dynamics (MD) simulations to improve our understanding of the dynamics, and hence, function and regulation of cytoskeletal proteins. Microtubules and kinesin motor proteins play a ...
Single-Cell Profiling of Paracrine Network and Immune Landscape in Non-Alcoholic Steatohepatitis
(2022)
The liver is a heterogeneous organ comprising a diverse array of cells including parenchymal hepatocytes, and non-parenchymal cells (NPCs) including endothelial cells, hepatic stellate cells, cholangiocytes, and various ...
On the Phenotype of White-tailed Deer Antlerogenic Progenitor Cells.
(2013)
Repair of large bone defects is one of the key unmet clinical needs in musculoskeletal medicine. A rare exception to the limits of mammalian regeneration is the deer antler, the only example of complete, repeated organ ...