Now showing items 1211-1220 of 1250
On the Phenotype of White-tailed Deer Antlerogenic Progenitor Cells.
(2013)
Repair of large bone defects is one of the key unmet clinical needs in musculoskeletal medicine. A rare exception to the limits of mammalian regeneration is the deer antler, the only example of complete, repeated organ ...
Regulation of Adipocyte Differentiation and Metabolism by Artificial Sweeteners and Sweet Taste Receptors.
(2013)
To maintain energetic homeostasis, adipose tissue must be uniquely sensitive to nutritional status. One mechanism for nutrient sensing in metabolic systems is through sweet taste receptors, which are intrinsically sensitive ...
How a Novel Zinc Finger Domain Improves Target Gene Selection by TCF in WNT/ß-Catenin Signaling.
(2014)
The Wnt/beta-catenin pathway is a highly conserved signaling pathway that plays an important role in metazoan development. T-cell factors (TCF) are transcription factors that regulate the transcription of many Wnt target ...
SOX10-Regulated Promoter Use Defines Isoform-Specific Gene Expression in Schwann Cells
(2019)
To support the development of diverse cell types, multicellular organisms have adopted mechanisms to tailor gene expression profiles to specific spatial and temporal contexts. These mechanisms—including alternative promoter ...
The Role of Wnt Signaling in Adrenocortical Homeostasis.
(2014)
Wnt/beta-catenin signaling is critical for adrenal homeostasis. To elucidate how Wnt/beta-catenin signaling elicits homeostatic maintenance of the adrenal cortex, we characterized the identity of the adrenocortical ...
Regulatory Signaling Networks Governing Budding Yeast Filamentous Growth.
(2014)
In response to specific stresses, the budding yeast Saccharomyces cerevisiae undergoes a morphogenetic program wherein cells elongate and interconnect, forming pseudohyphal filaments. This filamentous growth transition has ...
There and Back Again: Regulation of Stem Cell Homeostasis and Dedifferentiation in the Drosophila Male Germline by me31b
(2021)
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. However, even stem cells can be damaged or lost, leading to a tissue that ...
Identifying Signaling Pathways Mediating Filamentous Growth in Saccharomyces Cerevisiae.
(2013)
Multiple fungal species exhibit complex morphological changes in response to environmental conditions. Notably, the ability to transition between a cellular yeast-like form and a filamentous form is linked to virulence in ...
Structural and Biochemical Mechanisms of MLL1 Activation on Chromatin
(2022)
Transcription is a critical process by which cells regulate temporal and spatial expression of genes. In eukaryotes, histone H3 lysine 4 methylation by the MLL/SET1 family histone methyltransferases is enriched at transcription ...
Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
(2017)
FoxO transcription factors promote longevity across diverse organisms through upregulation of
parallel stress responses. Therefore, understanding how FoxO activity is regulated may provide
insights for improving overall ...