Now showing items 1221-1230 of 1250
Molecular Mechanisms of Autophagy Induction and Mitochondrial Degradation in the Yeast Saccharomyces cerevisiae.
(2014)
Eukaryotic cells rely on autophagy to degrade damaged or excess proteins and organelles. Autophagy can occur in either nonselective or selective modes. Nonselective autophagy sequesters bulk cytoplasm; in contrast, selective ...
A Poised Negative Feedback Circuit Balances Continual Self-Renewal with Rapid Restriction of Developmental Potential across Asymmetric Stem Cell Division.
(2016)
The identities of stem cells and their differentiated progeny are controlled by transcription factor networks that interact with chromatin modifying enzymes to package the genome into active and repressed domains. These ...
Identification of the PH Domain of Scaffold Protein SH2B1 as a Critical Regulator of Energy Balance and Glucose Metabolism
(2019)
Obesity is a growing epidemic but the cellular and molecular mechanisms underlying obesity are still not well understood. Mutations in the adaptor protein SH2B1 have been identified in individuals with severe early-onset ...
Contrasting Functions of Notch Signaling In Normal and Pathogenic Adrenal Biology.
(2012)
Cell-cell communication is essential for proper development and homeostasis, the dysregulation of which can manifest in developmental defects and/or cancer. The Notch signaling pathway is an evolutionarily conserved pathway ...
Identification, Localization, and Characterization of Hematopoietic Stem Cells and Their Niche.
(2010)
To improve our ability to identify HSCs and their localization in vivo we compared the gene expression profiles of highly purified hematopoietic stem cells (HSCs) and non-self-renewing multipotent progenitors (MPPs). Cell ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
An in Vitro and in Silico Kinetic Study of a Viral RNA Silencing Suppressor.
(2010)
RNA interference (RNAi) is a conserved gene regulatory mechanism employed by higher eukaryotes to avert emergent viruses and retrotransposons. During viral infection, the RNase III-type endonuclease Dicer cleaves viral ...
Structure, Function, and Evolution of a Signal-Regulated Enhancer.
(2010)
Enhancers are cis-regulatory elements that control the level, timing, and cell-type specificity of gene expression. Despite the central role that enhancers play in transcriptional regulation, the rules that govern their ...
Hox Function in Mammalian Kidney Development.
(2009)
The Hox gene complexes encode an evolutionarily conserved set of transcription factors important for the anteroposterior (AP) patterning of the body plan, and are essential for the proper development of many organ systems, ...