Now showing items 1231-1240 of 1250
Pooling Designs for High-Throughput Biological Experiments.
(2010)
High-throughput experiments provide a fast, automated way to obtain massive amounts of information about biological systems. In several instances, these experiments subject a large number of items (biological samples or ...
Role of B-Catenin Signaling in Adrenocortical Development and Tumorigenesis
(2009)
Wnt/β-catenin signaling plays many important roles during mammalian development. In the adrenal cortex, perturbations in the signaling pathway are associated with abnormal development and adrenocortical tumorigenesis. Loss- ...
Hedgehog-Wnt Interactions during Pathologic Epithelial Bud Development and Skin Tumorigenesis.
(2010)
The Hedgehog (Hh) and canonical Wnt/beta-catenin signaling pathways are involved in various embryonic processes, and when aberrantly activated after birth in certain cell types or settings, are associated with the development ...
Crosstalk between Endothelial Cells and Tumor Cells in Head and Neck Cancer
(2009)
Tumor angiogenesis is necessary for cancer progression and requires active interaction between endothelial cells and tumor cells. It is well established that cancer cells secrete angiogenic factors to recruit and sustain ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Activity-Dependent Regulation of Ether á … go-go K+ Channels.
(2008)
The Drosophila ether á go-go (eag) gene encodes a partially inactivating, voltage-gated K+ channel expressed at neuromuscular and CNS synapses. Recordings from the larval neuromuscular junctions (NMJs) of eag mutants, ...
Proteoglycan-4: A Dynamic Regulator of Parathyroid Hormone Biologic Actions.
(2011)
Intermittent parathyroid hormone (PTH) (1-34) is the only anabolic agent currently approved for the treatment of osteoporosis in the U.S. PTH (1-34) is under clinical investigations as a local bone regenerative therapy ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Novel Strategies in Cocaine Esterase Modification for Treatment of Cocaine Intoxication.
(2011)
Cocaine esterase (CocE) is the most efficient cocaine-metabolizing enzyme tested in vivo to date, displaying a rapid clearance of cocaine and a robust protection against cocaine's toxicity. A major obstacle to the clinical ...