Now showing items 51-60 of 562
A covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination
(Wiley Periodicals, Inc., 2017-05-02)
Enhancer of zeste homolog 2 (EZH2) has been characterized as a critical oncogene and a promising drug target in human malignant tumors. The current EZH2 inhibitors strongly suppress the enhanced enzymatic function of mutant ...
Conservation and revised annotation of the T reponema denticola prcB‐prcA‐prtP locus encoding the dentilisin ( CTLP ) protease complex
(Wiley Periodicals, Inc., 2013-06)
FGF22 signaling regulates synapse formation during post‐injury remodeling of the spinal cord
(Wiley Periodicals, Inc., 2015-05-05)
The remodeling of axonal circuits after injury requires the formation of new synaptic contacts to enable functional recovery. Which molecular signals initiate such axonal and synaptic reorganisation in the adult central ...
Axial level‐specific regulation of neuronal development: Lessons from PITX2
(Wiley Periodicals, Inc., 2015-02)
Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models
(John Wiley & Sons, 2015-05)
In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results ...
Extent and distribution of linkage disequilibrium in the Old Order Amish
(Wiley Subscription Services, Inc., A Wiley Company, 2010-02)
Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not ...
Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes
(Wiley Periodicals, Inc.Prentice‐Hall, 2019-07)
With the availability of large‐scale biobanks, genome‐wide scale phenome‐wide association studies are being instrumental in discovering novel genetic variants associated with clinical phenotypes. As increasing number of ...
A near death experience: Shigella manipulates host death machinery to silence innate immunity
(Wiley Periodicals, Inc., 2014-10-01)
FIP 5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis
(Wiley Periodicals, Inc., 2014-04)
Apical lumen formation is a key step during epithelial morphogenesis. The establishment of the apical lumen is a complex process that involves coordinated changes in plasma membrane composition, endocytic transport, and ...
Temporal orchestration of circadian autophagy rhythm by C/EBPβ
(John Wiley & Sons, Ltd, 2011-11-16)