Now showing items 101-110 of 121
New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences
(Battelle Memorial InstituteWiley Periodicals, Inc., 2012-09)
Proteomic analysis of estrogen response of premalignant human breast cells using a 2-D liquid separation/mass mapping technique
(WILEY-VCH Verlag, 2006-07)
A 2-D liquid-phase separation method based on chromatofocusing and nonporous silica RP-HPLC followed by ESI-TOF-MS was used to analyze proteins in whole cell lysates from estrogen-treated and untreated premalignant, ...
Effect of fixation temperature on flow cytometric measurement of intracellular antibody content of hybridomas during batch culture
(Kluwer Academic Publishers; Science & Technology Letters ; Springer Science+Business Media, 1993-04)
In order to investigate the effect of fixation temperature on flow cytometric measurement of intracellular antibody content of hybridoma cells, cells in different growth stages during a batch culture were fixed and stored ...
ProTrack: An Interactive Multi‐Omics Data Browser for Proteogenomic Studies
(Wiley Periodicals, Inc., 2020-11)
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) initiative has generated extensive multi‐omics data resources of deep proteogenomic profiles for multiple cancer types. To enable the broader community of biological ...
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
(Humana PressWiley Periodicals, Inc., 2020-06)
FRACPRED- 2D- PRM: A Fraction Prediction Algorithm- Assisted 2D Liquid Chromatography- Based Parallel Reaction Monitoring- Mass Spectrometry Approach for Measuring Low- Abundance Proteins in Human Plasma
(Wiley Periodicals, Inc., 2020-12)
Multidimensional fractionation- based enrichment methods improve the sensitivity of proteomic analysis for low- abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...
(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan.
(2012)
Chapter 1: We evaluated the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan ...
Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy
(2016)
Misregulation of tau, an intrinsically disordered protein, is implicated in Alzheimer’s disease (AD) and more than 15 related tauopathies. These diseases are characterized by the accumulation of tau aggregates into insoluble ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...