Now showing items 4381-4390 of 4391
CEP162 Deficiency Causes Human Retinal Degeneration And Reveals A Dual Role In Ciliogenesis And Neurogenesis
(2023)
Primary cilia are antenna-like cellular organelles that protrude from the plasma membrane to detect extracellular signals and to regulate cellular physiology. They are present in virtually all post-mitotic cells and ...
Lip service: Histological phenotypes correlate with diet and feeding ecology in herbivorous pacus
(John Wiley & Sons, Inc., 2023-02)
Complex prey processing requires the repositioning of food between the teeth, as modulated by a soft tissue appendage like a tongue or lips. In this study, we trace the evolution of lips and ligaments, which are used during ...
Assessment of renal outcome following therapy in monoclonal immunoglobulin deposition disease: Emphasizing the need for a consensus approach
(John Wiley & Sons, Inc., 2023-03)
Monoclonal immunoglobulin deposition disease (MIDD), often associated with plasma cell dyscrasias, predominantly affects the kidneys. In this disease, hematologic response (HR) to treatment can be reliably assessed by ...
Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology
(John Wiley & Sons, Inc., 2023-02)
Inorganic arsenic (iAs) is one of the largest toxic exposures to impact humanity worldwide. Exposure to iAs during pregnancy may disrupt the proper remodeling of the epigenome of F1 developing offspring and potentially ...
Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin-expressing interneurons, and inhibitory function in the auditory cortex
(John Wiley & Sons, Inc., 2023-02)
For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are ...
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
(John Wiley & Sons, Inc., 2023-03)
The treatment of patients with relapsed or refractory lymphoid neoplasms represents a significant clinical challenge. Here, we identify the pro-survival BCL-2 protein family member MCL-1 as a resistance factor for the BCL-2 ...
Reproductive Impact of Testosterone Therapy in a Transgender Mouse Model
(2024)
Long-term gender-affirming testosterone (T) therapy may negatively impact reproductive capacity for transgender men transitioning from female to male. Given clinical guidelines assuming fertility loss and anecdotal evidence ...
Mapping the Metabolic Landscape of the Healthy Human Pancreas and the Pancreatic Tumor Microenvironment
(2024)
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with a current 5-year survival rate of 13% (1). PDA accounts for ~90% of pancreatic cancer cases and arises from the exocrine tissue – responsible for digestive ...
Machine Learning Guided Drug Discovery: Comprehensive Application in Janus Kinase Inhibitor Design
(2023)
Conventional drug discovery is often plagued by resource-intensive processes, leading to significant attrition rates due to challenges such as efficacy shortcomings, safety concerns and suboptimal pharmacokinetics (PK). ...