Now showing items 141-150 of 209
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
(Springer-Verlag, 2005-07)
Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic–pituitary–adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, ...
Effects of tobacco smoking on the topographic eeg II
(Elsevier, 1992-07)
Domino, Edward F., Mona Riskalla, Yingfan Zhang and Edsel Kim. Effects of tobacco smoking on the topographic EEG II. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1992, 16(4):463-482. 1. 1. Tobacco smokers are well ...
Self-administration of psychoactive substances by the monkey
(Springer-Verlag, 1969-01)
A method has been developed which permits monkeys to self-administer drug solutions, at will, through indwelling intravenous catheters. Psychological dependence on the effects of a drug occurs when a naive monkey voluntarily ...
Differential actions of m and n cholinergic agonists on the brainstem activating system
(Elsevier, 1969-03)
The differential actions of i.v. arecoline and nicotine were determined on neocortical and limbic system EEG activation in acute rostral and caudal midbrain transected cats. All animals were prepared under diethyl ether ...
Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP
(Springer-Verlag, 1987-12)
Pigeons were trained to discriminate either a fixed dose of PCP (1 mg/kg; n =3) or a progressively decreasing dose (1-0.56–0.32 mg/kg; n =4) from saline. Lowering of the training dose shifted the dose-effect curve for PCP's ...
Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies
(Elsevier, 1987-09)
The excitatory amino acid antagonists -2-amino-5-phosphonovalerate (-AP5), its isomers -(-)-AP5 and -(+)-AP5, -2-amino-4-phosphonobutyrate (AP4), -2-amino-7-phosphonoheptanoate (AP7), [beta]--aspartylaminomethylphosphonic ...
Behavioural observations in gunn rats
(Springer-Verlag, 1978-01)
The Gunn rat is a hooded mutant of albino rat with various biochemical defects, including a low UDP-glucuronosyl-transferase activity. As a consequence, about half of their offspring are jaundiced from birth, due to high ...
Differential effects of nicotine on alcohol consumption in men and women
(Springer-Verlag, 2006-05)
Nicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women ...
Methoclocinnamox: time course of changes in alfentanil-reinforced responding in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-03)
Rationale : Methoclocinnamox (MC-CAM) possesses initial partial µ-opioid agonist activity with subsequent long-lasting µ-antagonist effects. This profile of activity is similar to that of buprenorphine, a compound with ...
Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Simultaneous and sequential drug use among clinical populations is the norm, whereas the pattern of self-administration of multiple drugs among non-human primate populations has not been thoroughly explored. ...