Now showing items 721-730 of 784
Origin of Low Detection Limit and High Selectivity of Roche Accu‐Chek Test Strips that Enables Measurement of Tear Glucose Levels
(WILEY‐VCH Verlag, 2015-03)
Tear glucose measurements have been suggested as a potential alternative to blood glucose monitoring for diabetic patients. While previous work has reported a correlation between blood and tear glucose levels in humans, ...
Solid‐Phase Synthesis of Branched Oligonucleotides
(Wiley Periodicals, Inc.Academic Press, 2002-06)
Branched nucleic acids (bNAs) have been of particular interest since the discovery of RNA forks and lariats as intermediates of nuclear mRNA splicing, as well as multicopy, single‐stranded DNA (msDNA). Such molecules contain ...
Chemical and Enzymatic Methods for Preparing Circular Single‐Stranded DNAs
(CRC PressWiley Periodicals, Inc., 2000-02)
Small circular oligonucleotides can be used for diagnostic, therapeutic, and laboratory purposes. These systems have gained considerable attention in recent years because they form unusually strong and specific complexes ...
Copy number variants are produced in response to low‐dose ionizing radiation in cultured cells
(Wiley Periodicals, Inc., 2014-03)
3′‐Modified Oligonucleotides and their Conjugates
(Wiley Periodicals, Inc.Pierce Chemical Company, 2000-12)
Solid‐phase synthesis of 3′‐aminoalkyl, 3′‐thioalkyl, and 3′‐polyethyleneglycol are described. The first two are important as specific points of attachment for a large variety of reporter groups; the latter is important ...
Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis
(John Wiley & Sons, Ltd., 2005-07)
Dendritic cells (DCs) retrovirally transduced with IL-4 have recently been shown to inhibit murine collagen-induced arthritis and associated Th1 immune responses in vivo , but the mechanisms that underly these effects are ...
Probing Nucleic Acid Structure with Nickel‐ and Cobalt‐Based Reagents
(Kluwer Academic PublishersWiley Periodicals, Inc., 2000-02)
The use of nickel and cobalt reagents is presented for characterizing the solvent exposure of guanine residues in DNA and RNA. These reagents promote guanine oxidation in the presence of a peracid such as monopersulfate, ...
Testing cross‐phenotype effects of rare variants in longitudinal studies of complex traits
(John Wiley & Sons, 2018-06)
Many gene mapping studies of complex traits have identified genes or variants that influence multiple phenotypes. With the advent of next‐generation sequencing technology, there has been substantial interest in identifying ...
Regulated expression of polysaccharide utilization and capsular biosynthesis loci in biofilm and planktonic Bacteroides thetaiotaomicron during growth in chemostats
(Wiley Periodicals, Inc., 2014-01)
Bacteroides thetaiotaomicron is a prominent member of the human distal gut microbiota that specializes in breaking down diet and host‐derived polysaccharides. While polysaccharide utilization has been well studied in B. ...
New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences
(Battelle Memorial InstituteWiley Periodicals, Inc., 2012-09)