Now showing items 751-760 of 784
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo
(Wiley Periodicals, Inc., 2020-01)
Metastases are preceded by stochastic formation of a hospitable microenvironment known as the premetastatic niche, which has been difficult to study. Herein, we employ implantable polycaprolactone scaffolds as an engineered ...
CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts
(Wiley Periodicals, Inc., 2021-04)
This study elucidates the mechanism of CCL25 and CCR9 in rheumatoid arthritis (RA). RA synovial fluid (SF) expresses elevated levels of CCL25 compared to OA SF and plasma from RA and normal. CCL25 was released into RA SF ...
The holy basil administration diminishes the NF-kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma
(John Wiley & Sons, Ltd., 2022-04)
Bacterial pneumonia is one of the most important causes of mortality in the United States. The bacteria Klebsiella pneumoniae (KP) accounts for a significant proportion of community and hospital-acquired infections. Here, ...
Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
(SpringerWiley Periodicals, Inc., 2019-10-15)
One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self‐organizing system that can undergo autonomous ...
FRACPRED- 2D- PRM: A Fraction Prediction Algorithm- Assisted 2D Liquid Chromatography- Based Parallel Reaction Monitoring- Mass Spectrometry Approach for Measuring Low- Abundance Proteins in Human Plasma
(Wiley Periodicals, Inc., 2020-12)
Multidimensional fractionation- based enrichment methods improve the sensitivity of proteomic analysis for low- abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive ...
3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing
(John Wiley & Sons, Inc., 2020-04)
MultiFlow® DNA Damage—p53, γH2AX, Phospho‐Histone H3 is a miniaturized, flow cytometry‐based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to ...
A concept‐wide association study to identify potential risk factors for nonadherence among prevalent users of antihypertensives
(Wiley Periodicals, Inc., 2019-10)
PurposeWe sought to determine whether an association study using information contained in clinical notes could identify known and potentially novel risk factors for nonadherence to antihypertensive medications.MethodsWe ...
Combining sequence data from multiple studies: Impact of analysis strategies on rare variant calling and association results
(Wiley Periodicals, Inc., 2020-01)
Individual sequencing studies often have limited sample sizes and so limited power to detect trait associations with rare variants. A common strategy is to aggregate data from multiple studies. For studying rare variants, ...
Semiclassical transition state theory/master equation kinetics of HO + CO: Performance evaluation
(World ScientificWiley Periodicals, Inc., 2020-12)
Previously, master equation (ME) simulations using semiclassical transition state theory (SCTST) and high‐accuracy extrapolated ab initio thermochemistry (HEAT) predicted rate constants in excellent agreement with published ...