Now showing items 11-20 of 422
The Oxidation of the Endogenous Cannabinoid Anandamide and the Synthetic Cannabinoid JWH-018, a Drug of Abuse, by Human Cytochrome P450 2J2.
(2014)
Cytochrome P450s (CYPs) are a superfamily of monooxygenases catalyzing the metabolism of various endogenous and exogenous compounds. CYP2J2 is highly expressed in the cardiovascular system and catalyzes the metabolism of ...
Systems pharmacology modeling: an approach to improving drug safety
(Wiley Periodicals, Inc.University of Washington, 2014-01)
Advances in systems biology in conjunction with the expansion in knowledge of drug effects and diseases present an unprecedented opportunity to extend traditional pharmacokinetic and pharmacodynamic modeling/analysis to ...
The Impact of Sonication on the Surface Quality of Single‐Walled Carbon Nanotubes
(NIST Special PublicationWiley Periodicals, Inc., 2015-08)
Addressing Medication Nonadherence Using Mobile Phone-Based Tailored Messaging.
(2014)
While numerous treatments exist to manage diabetes, adherence to guideline-recommended medications remains suboptimal. Both tailoring health messages and text messaging have been observed to improve medication adherence, ...
Access to Investigational Drugs: FDA Expanded Access Programs or “Right‐to‐Try” Legislation?
(Wiley Periodicals, Inc., 2015-10)
PurposeThe Food and Drug Administration Expanded Access (EA) program and “Right‐to‐Try” legislation aim to provide seriously ill patients who have no other comparable treatment options to gain access to investigational ...
Contribution of Renal and Non‐Renal Clearance on Increased Total Clearance of Adalimumab in Glomerular Disease
(Wiley Periodicals, Inc., 2013-09)
The contribution of renal and non‐renal clearance toward targeted concentrations and/or effects of therapeutic proteins in nephrotic patients are unknown. This study dissected the contribution of clearance pathways to ...
Comparison of in vitro – in vivo extrapolation of biliary clearance using an empirical scaling factor versus transport‐based scaling factors in sandwich‐cultured rat hepatocytes
(Wiley Subscription Services, Inc., A Wiley Company, 2013-08)
Biliary clearance (CL b ) is often underestimated by in vitro – in vivo extrapolation from sandwich‐cultured hepatocytes (SCHs). The objective of this study was to compare the performance of a universal correction factor ...
Successfully Accelerating Translational Research at an Academic Medical Center: The University of Michigan-Coulter Translational Research Partnership Program
(Blackwell Publishing Inc, 2010-12)
Translational research encompasses the effective movement of new knowledge and discoveries into new approaches for prevention, diagnosis, and treatment of disease. There are many roadblocks to successful bench to bedside ...
Improved Targeting and Biopharmaceutical Properties of Prodrugs of Anti-infective Agents.
(2013)
The prodrug strategy has been frequently used as a chemical approach for the enhancement of certain disadvantages of parent drugs. In this dissertation, I synthesized prodrugs of two anti-infective agents, ganciclovir and ...
Drug‐like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase
(Blackwell Publishing LtdWiley Periodicals, Inc., 2011-10)