Now showing items 21-30 of 53
The interaction between C 5a and both C 5a R and C 5 L 2 receptors is required for production of G ‐ CSF during acute inflammation
(Wiley Periodicals, Inc., 2013-07)
Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells
(Wiley Periodicals, Inc.Systems Biology, 2017-09)
The development of resistance to targeted therapeutics is a challenging issue for the treatment of cancer. Cancers that have mutations in BRCA, a DNA repair protein, have been treated with poly(ADP‐ribose) polymerase (PARP) ...
LC/MS/MS analysis of the endogenous dimethyltryptamine hallucinogens, their precursors, and major metabolites in rat pineal gland microdialysate
(Alan R. LissWiley Periodicals, Inc., 2013-12)
We report a qualitative liquid chromatography–tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N , N ‐dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, ...
Production of cellulosic organic acids via synthetic fungal consortia
(Wiley Periodicals, Inc., 2018-04)
Consolidated bioprocessing (CBP) is a potential breakthrough technology for reducing costs of biochemical production from lignocellulosic biomass. Production of cellulase enzymes, saccharification of lignocellulose, and ...
Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC‐Q‐TOF/MS and multivariate data analysis
(Wiley Periodicals, Inc., 2017-12)
Cationic liposomes (CLs) are novel nonviral vectors widely used for delivering drugs or genes. However, applications of CLs are largely hampered by their cytotoxicity, partly because the potential mechanism underlying the ...
CD24 on thymic APCs regulates negative selection of myelin antigen‐specific T lymphocytes
(Wiley Periodicals, Inc., 2012-04)
Inflammasomes as microbial sensors
(WILEY-VCH Verlag, 2010-03)
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1Β and IL-18. Recent studies ...
Sensitive detection of glucagon aggregation using amyloid fibril‐specific antibodies
(Wiley Periodicals, Inc., 2019-08)
Sensitive detection of protein aggregates is important for evaluating the quality of biopharmaceuticals and detecting misfolded proteins in several neurodegenerative diseases. However, it is challenging to detect extremely ...
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome
(WILEY-VCH Verlag, 2010-03)
Cerebral malaria is the most severe complication of Plasmodium falciparum infection in humans and the pathogenesis is still unclear. Using the P. berghei ANKA infection model of mice, we investigated a potential ...