Now showing items 1891-1900 of 1943
Structures of Exocyst Subunit Exo70 from Yeast and Mouse.
(2007)
Exocytosis is a eukaryotic process in which vesicles deliver membrane and other cargoes to and across the plasma membrane. The exocyst is a tethering complex necessary for the polarization and fusion of exocytic vesicles ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Changes in Gait Variability Across the Lifespan in Persons with Down Syndrome.
(2009)
Variability is always present during repetitive movements. Scholars have studied human movement patterns for years, but have only recently begun to focus on variability as something other than noise or error. I followed ...
Herpesvirus Infection Augments the Response to a Subsequent Fibrotic Challenge in the Lung Via the Recruitment of Fibrocytes and the Induction of Pro-fibrotic Factors.
(2009)
No effective treatment currently exists for pulmonary fibrosis. The cause of pulmonary fibrosis is unknown, and little is known about its pathobiology. While pulmonary fibrosis is likely multifactorial, evidence is ...
On Improving the Effectiveness of Control Signals from Chronic Microelectrodes for Cortical Neuroprostheses.
(2009)
Using microelectrodes, we can record neural signals which can eventually be used to control cortical neuroprostheses for assisting people with spinal-cord trauma, stroke deficits, amyotrophic lateral sclerosis (ALS), and ...
Gastrointestinal Motility Variation and Oral Drug Absorption.
(2008)
Gastrointestinal (GI) motility is a physiological factor that affects oral drug absorption by controlling a drug's residence time in the GI tract. The development of an oral drug absorption model, the pulsatile emptying ...
The Role of Lipoate Dependent Metabolism During Intracellular Growth and Pathogenesis of Listeria monocytogenes.
(2009)
The Gram-positive bacterial pathogen Listeria monocytogenes replicates rapidly in the host cytosol, indicating it efficiently utilizes host-derived nutrients. The critical co-factor lipoate is one nutrient this bacterium ...
Factors Influencing Opioid Receptor Signaling to Adenylyl Cyclase.
(2010)
Opioids, such as morphine, signal through G protein-coupled receptors that are linked to adenylyl cyclase (AC)-inhibitory (Gi/o) heterotrimeric GTP-binding proteins. The transduction of signal from opioid receptor to G ...
Medical Ultrasound Aberration Correction via Acoustic Droplet Vaporization and Time-Reversal Acoustics.
(2009)
Time-reversal acoustics (TRA) is an alternative to standard focusing approaches in medical ultrasound. TRA records backscattered ultrasound and time-reverses it (Ψ(t) -> Ψ(−t)). Due to the time-reversal invariance of the ...
The Role of SUMO Modification in the Regulation of Kv1.5, a Major Cardiovascular Potassium Channel.
(2010)
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States. A major limitation to current antiarrhythmic medications used to treat AF is the occurrence of potentially life-threatening, proarrhythmic, ...