Now showing items 71-80 of 843
Compound heterozygosity for loss‐of‐function FARSB variants in a patient with classic features of recessive aminoacyl‐tRNA synthetase‐related disease
(Wiley Periodicals, Inc., 2018-06)
Aminoacyl‐tRNA synthetases (ARSs) are ubiquitously expressed enzymes that ligate amino acids onto tRNA molecules. Genes encoding ARSs have been implicated in phenotypically diverse dominant and recessive human diseases. ...
Recent Workshops of the HUPO Human Plasma Proteome Project (HPPP): A bridge with the HUPO CardioVascular Initiative and the emergence of SRM targeted proteomics
(WILEY‐VCH Verlag, 2011-09)
We hereby provide a two‐year update on the HUPO Human Plasma Proteome Project (HPPP) informed by advances presented at the HPPP sessions at the HUPO World Congresses in Toronto in September 2009 and in Sydney in September 2010.
Self-Encapsulation of Vaccine Antigens in PLGA Microparticles and Microneedles.
(2016)
There is an urgent need to reduce reliance on hypodermic injections for many protein-based therapies. Alternative approaches include developing controlled release formulations, which reduce dosing frequencies, and utilizing ...
Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies
(Wiley Periodicals, Inc.Springer Verlag, 2017-10-30)
Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution
(John Wiley & Sons, Ltd, 2010-12-21)
Integrin alpha V beta 3 targeted dendrimer‐rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis
(Wiley Periodicals, Inc., 2018-11)
Therapeutic strategies targeting both cancer cells and associated cells in the tumor microenvironment offer significant promise in cancer therapy. We previously reported that generation 5 (G5) dendrimers conjugated with ...
Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy
(Wiley Periodicals, Inc., 2017-04)
Many prostate cancer (PCa) recurrences are thought to be due to reactivation of disseminated tumor cells (DTCs). We previously found a role of the TAM family of receptor tyrosine kinases TYRO3, AXL, and MERTK in PCa dormancy ...
Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research
(Wiley Subscription Services, Inc., A Wiley Company, 2011-01)
Primary rat hepatocytes are a widely used experimental model to estimate drug metabolism and toxicity. In currently used two-dimensional (2D) cell culture systems, typical problems like morphological changes and the loss ...
Microprinted feeder cells guide embryonic stem cell fate
(Wiley Subscription Services, Inc., A Wiley Company, 2011-10)
We introduce a non‐contact approach to microprint multiple types of feeder cells in a microarray format using immiscible aqueous solutions of two biopolymers. Droplets of cell suspension in the denser aqueous phase are ...