Now showing items 3441-3450 of 3514
Predicting the Formation Pathways and Morphologies of Oxygenated Carbonaceous Nanoparticle Precursors in Premixed Flames
(2017)
Organic nanoparticles are an inevitable by-product of combustion phenomena that have deleterious health and environmental effects. They are carcinogenic because they damage biological cells due to their small size and their ...
Multiscale Modeling of Polymer-Colloid Interactions in Waterborne Coatings
(2021)
Formulations containing rheology modifying polymers and nanometer sized colloids have widespread
use in pharmaceuticals, personal care products, and waterborne coatings. When combined
in solution, hydrophobic endcaps of ...
Micro-Particle Operations Using Asymmetric Traps
(2017)
Micro-particles are a great tool to detect biomolecules for their high multiplexing capability, wide options of materials, and scalability. Currently, most of the platforms utilizing micro-particles are bench-top scale ...
Developing and Applying Microdroplet Co-Cultivation Technology for Elucidating Bacterial Interspecies Interactions in the Human Vaginal Microbiome
(2020)
The role of the human vaginal microbiome (HVM) has gained increased recognition
due to recent technological advancements that helped link community composition
and women's health risks. However, the ecological roles of ...
A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides
(2018)
Cap-dependent protein translation (CdT) is dysregulated in many types of cancer and leads to overexpression of oncogenes promoting angiogenesis, evasion of apoptosis, and cell proliferation. The protein-protein interactions ...
Development of Modular, Droplet Microfluidic Workflows to Investigate Cellular Heterogeneity
(2023)
Cells exist in unique contexts within a population, but miniscule differences in their environment, epigenome, and cell cycle produce an assortment of observable characteristics in cells. Conventional cellular analysis ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Application of Ultra-low Circulating Biomarkers and Single Cell Analysis from Solid Tumors with Single Molecule Resolution
(2020)
Circulating tumor cells (CTCs) and extracellular vesicles (EVs) carry tumor-derived cargo in the circulation and provide the potential for minimally invasive patient monitoring. These circulating biomarkers have both been ...
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Innovations in Droplet Microfluidics for Enzyme Evolution
(2020)
High throughput screening (HTS) is a critical technology in discovery and process chemistry. Typically, HTS has relied on robotic handling of well plates of samples to rapidly perform and assess reactions, but novel ...